Tear glucose dynamics in diabetes mellitus
Tear glucose dynamics in diabetes mellitus
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DOI：
10.1080/02713680600976552
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发表时间：
2006-11-01
影响因子：
2
通讯作者：
Morris, Carol
中科院分区：
文献类型：
--
作者：
Lane, Jennifer D.;Krumholz, David M.;Morris, Carol
这项研究比较了 121 名糖尿病和非糖尿病受试者在摄入碳水化合物负荷后泪液葡萄糖动态差异。使用泪液葡萄糖的定量色谱分析，并且该值与血糖值相关。糖尿病和非糖尿病泪液葡萄糖平均值分别为 0.35 +/- 0.04 mmol/L 和 0.16 +/- 0.03 mmol/L。在受试者组中观察到泪液和毛细血管血糖值存在显着差异。观察到泪液葡萄糖和毛细血管血糖之间存在相关性。碳水化合物挑战后，泪液中葡萄糖的浓度与毛细血管血糖成比例变化。尽管可以单独使用泪液葡萄糖值来确定受试者的糖尿病状态，但在临床环境中，由于技术限制这可能不实用。
This study compares tear glucose dynamic differences between 121 diabetic and nondiabetic subjects after the administration of a carbohydrate load. A quantitative chromatographic analysis of tear glucose was used and the values correlated to blood glucose values. Diabetic and nondiabetic tear glucose mean values were 0.35 +/- 0.04 mmol/L and 0.16 +/- 0.03 mmol/L, respectively. Significant differences were observed among the subject groups in both the tear and capillary blood glucose values. A correlation between tear glucose and capillary blood glucose was observed. The concentration of glucose in the tear fluid changes proportionately with respect to capillary blood glucose after a carbohydrate challenge. Although it is possible to determine the diabetic status of a subject using tear glucose values alone, in the clinical setting this may not prove to be practical due to technical limitations.