Occipital cortical morphology of the rat: Alterations with age and environment
Occipital cortical morphology of the rat: Alterations with age and environment
复制标题
大鼠枕叶皮质形态：随年龄和环境的变化
DOI：
10.1016/0014-4886(80)90074-6
复制
发表时间：
1980
影响因子：
5.3
通讯作者：
R. Johnson
中科院分区：
文献类型：
--
作者：
J. Connor;M. Diamond;R. Johnson
与高尔基体浸渍的使用，这项研究表明，在第二和第三层的内侧枕叶皮质的444和630天的雄性大鼠的树突状细胞增殖。在富集或标准菌落条件下饲养的动物中出现增加。具体而言，第三和第四阶基底树突的频率显着增加，从414至444至630天的年龄。本研究近似于纵向研究，因为不同年龄组为同窝仔。老年人树突分支增加的发现并不新鲜，但我们的研究是第一次注意到老鼠大脑皮层的这种增加。在一项单独的研究中，对90天和630天大的大鼠的皮质形态进行了检查，这些大鼠在单一的丰富环境中共同生活了30天。将这些大鼠的大脑与在标准群体条件下与其相应年龄组生活在一起的同窝出生大鼠进行比较。树突模式是相似的，在这两个年龄组，无论环境。只有第六阶有显著差异，在630日龄的动物中分支的频率更高。与对照组相比，富集动物的皮质厚度明显增加，但差异不显著。由于先前的结果显示，60至90天大的没有老年同伴的富营养大鼠比标准对照组的同窝大鼠发育出明显更厚的皮质，因此当年轻大鼠与老年大鼠生活在一起时，它们可能不会像与其他年轻大鼠生活在一起时那样与环境相互作用。
With the use of Golgi impregnation, this study demonstrated dendritic proliferation in layers II and III in the medial occipital cortex of 444- and 630-day-old male rats. Increases occurred in animals housed in either enriched or standard colony conditions. Specifically, third- and fourth-order basal dendrites increased significantly in frequency from 414 to 444 to 630 days of age. This study approximated a longitudinal study because the different age groups were littermates. The finding of an increase in dendritic branching in old age was not new, but our study was the first to note this increase in the rat's cerebral cortex. In a separate study the cortical morphology was examined in 90- and 630-day-old rats which had been living together in a single enriched environment for 30 days. The brains of these rats were compared with littermates living with their respective age groups in standard colony conditions. The dendritic pattern was similar in those two age groups irrespective of environment. Only the sixth order significantly differed, with the frequency of branching being greater in the 630-day-old animals. An increase in cortical thickness in the enriched animals was apparent compared with controls, but the differences were not significant. Because previous results showed the 60- to 90-day-old enriched rats without old companions developed a significantly thicker cortex than standard control littermates, it is possible that when young rats live with old rats they do not interact with their environment as musch as when living with other young rats.