Disrupted modular architecture of cerebellum in schizophrenia: a graph theoretic analysis.
Disrupted modular architecture of cerebellum in schizophrenia: a graph theoretic analysis.
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DOI：
10.1093/schbul/sbu059
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发表时间：
2014-11-01
影响因子：
6.6
通讯作者：
Hetrick, William P
中科院分区：
文献类型：
--
作者：
Kim, Dae-Jin;Kent, Jerillyn S;Hetrick, William P
最近对精神分裂症的研究表明，认知和记忆缺陷伴随着大脑皮层和皮层下区域神经元连接的中断。最近，在精神分裂症的结构网络的拓扑组织的变化也被识别使用图理论分析。然而，小脑在这种网络结构中的作用在很大程度上仍然未知。在这项研究中，我们对25名精神分裂症患者和36名健康志愿者的小脑进行了弥散张量成像获得的全局网络测量。虽然精神分裂症患者的小脑全球网络特征与健康对照组相比略有改变，但患者表现出保留的小世界网络组织。然而，模块化架构的改变主要是在第二课。此外，通过测量小叶I-IV和x的分数各向异性（FA），精神分裂症患者的模块化与微结构完整性之间的相关性降低。最后，FA的改变与精神分裂症患者的阳性和阴性综合征量表症状评分显著相关。综上所述，我们的数据表明，精神分裂症患者小脑网络结构改变，局部微结构连通性降低，小脑结构异常是精神分裂症的相关症状。
Recent studies of schizophrenia have revealed cognitive and memory deficits that are accompanied by disruptions of neuronal connectivity in cortical and subcortical brain regions. More recently, alterations of topological organization of structural networks in schizophrenia are also being identified using graph theoretical analysis. However, the role of the cerebellum in this network structure remains largely unknown. In this study, global network measures obtained from diffusion tensor imaging were computed in the cerebella of 25 patients with schizophrenia and 36 healthy volunteers. While cerebellar global network characteristics were slightly altered in schizophrenia patients compared with healthy controls, the patients showed a retained small-world network organization. The modular architecture, however, was changed mainly in crus II. Furthermore, schizophrenia patients had reduced correlations between modularity and microstructural integrity, as measured by fractional anisotropy (FA) in lobules I-IV and X. Finally, FA alterations were significantly correlated with the Positive and Negative Syndrome Scale symptom scores in schizophrenia patients. Taken together, our data suggest that schizophrenia patients have altered network architecture in the cerebellum with reduced local microstructural connectivity and that cerebellar structural abnormalities are associated symptoms of the disorder.