Low coherence interferometer for sensing retardance change during neural activity.
Low coherence interferometer for sensing retardance change during neural activity.
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低相干干涉仪，用于感测神经活动期间的延迟变化。
DOI：
10.1109/iembs.2009.5333179
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Akkin,Taner
中科院分区：
文献类型：
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作者：
Al-Kaisi,MuhammadK;Landowne,David;Akkin,Taner
各种光学测量，包括延迟/双折射变化，揭示了与动作电位传播相关的瞬态光学和结构变化。通过开发新技术和改进当前方法可以更好地理解这些变化。为了检测受刺激神经中的瞬态延迟变化，我们提出了一种利用基于保偏光纤的干涉仪的两个正交偏振通道的微分相位技术。该系统卓越的灵敏度（10.4 pm）有望实现反射模式下动作电位传播的非接触式光学测量，并研究神经活动期间的瞬态延迟变化。
A variety of optical measurements, including retardance/birefringence change, have revealed transient optical and structural changes associated with action potential propagation. Those changes can be understood better by developing new techniques and improving the current approaches. To detect transient retardance changes in a stimulated nerve, we propose a differential phase technique utilizing two orthogonal polarization channels of a polarization-maintaining fiber based interferometer. The superior sensitivity of the system (10.4 pm) is promising to achieve a non-contact optical measurement of action potential propagation in reflection mode, and to study the transient retardance changes during neural activity.