NF-Y (CBF) regulation in specific cell types and mouse models.
NF-Y (CBF) regulation in specific cell types and mouse models.
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DOI：
10.1016/j.bbagrm.2016.10.014
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发表时间：
2017-05
期刊：
影响因子：
--
通讯作者：
Maity SN
中科院分区：
文献类型：
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作者：
Maity SN
CCAAT结合因子CBF/NF-Y是细胞增殖和早期胚胎发育所必需的。核因子-Y可以调节不同细胞类型特异性基因的表达，这些基因由不同的生理信号通路激活。在硬皮病、神经退行性疾病和癌症等人类的致病疾病中，可以观察到核因子-Y的失调。在小鼠身上的条件灭活的核因子-YA基因表明，核因子-Y的活性对于正常的组织稳态、生存和代谢功能是必不可少的。总之，核因子-Y是一种重要的转录因子，在哺乳动物从早期到成年期的发育过程中发挥着关键作用，在人类的发病机制中也发挥着重要作用。
The CCAAT-binding factor CBF/NF-Y is needed for cell proliferation and early embryonic development. NF-Y can regulate the expression of different cell type-specific genes that are activated by various physiological signaling pathways. Dysregulation of NF-Y was observed in pathogenic conditions in humans such as scleroderma, neurodegenerative disease, and cancer. Conditional inactivation of the NF-YA gene in mice demonstrated that NF-Y activity is essential for normal tissue homeostasis, survival, and metabolic function. Altogether, NF-Y is an essential transcription factor that plays a critical role in mammalian development, from the early stages to adulthood, and in human pathogenesis.