Drosophila neuroblasts sequentially express transcription factors which specify the temporal identity of their neuronal progeny
Drosophila neuroblasts sequentially express transcription factors which specify the temporal identity of their neuronal progeny
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DOI：
10.1016/s0092-8674(01)00465-2
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发表时间：
2001-08-24
期刊：
影响因子：
64.5
通讯作者：
Doe, CQ
中科院分区：
文献类型：
--
作者：
Isshiki, T;Pearson, B;Doe, CQ
神经前体通常以特定的顺序产生不同的细胞类型，但调控细胞命运指定的内在或外在线索却鲜为人知。在这里，我们发现果蝇的神经前体(神经母细胞)顺序表达转录因子Hunchback-->；Kruppel-->；Pdm-->；Castor，分化的后代维持其出生时存在的转录因子谱。驼背对于第一个出生的细胞命运是必要的和充分的，而克鲁佩尔对于第二个出生的细胞命运是必要的和充分的；这在多个谱系中被观察到，并且与所涉及的细胞类型无关。我们认为，驼背和Kruppel控制着神经母细胞系中早期出生的时间同一性。
Neural precursors often generate distinct cell types in a specific order, but the intrinsic or extrinsic cues regulating the timing of cell fate specification are poorly understood. Here we show that Drosophila neural precursors (neuroblasts) sequentially express the transcription factors Hunchback --> Kruppel --> Pdm --> Castor, with differentiated progeny maintaining the transcription factor profile present at their birth. Hunchback is necessary and sufficient for first-born cell fates, whereas Kruppel is necessary and sufficient for second-born cell fates; this is observed in multiple lineages and is independent of the cell type involved. We propose that Hunchback and Kruppel control early-born temporal identity in neuroblast cell lineages.