Evidence for excessive frontal evoked gamma oscillatory activity in schizophrenia during working memory
Evidence for excessive frontal evoked gamma oscillatory activity in schizophrenia during working memory
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DOI：
10.1016/j.schres.2010.05.023
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发表时间：
2010-08-01
影响因子：
4.5
通讯作者：
Daskalakis, Z. J.
中科院分区：
文献类型：
--
作者：
Barr, M. S.;Farzan, F.;Daskalakis, Z. J.
精神分裂症(SCZ)患者在工作记忆(WM)过程中诱发的伽马(伽马)振荡(30-50赫兹)会发生改变。然而，诱发的额叶振荡活动、西医表现和症状严重程度之间的关系的本质尚未确定。这项研究有两个目标。首先，通过检测SCZ患者与健康受试者在N-back任务中的Delta、theta、Alpha、Beta和Gamma(Delta、theta、Alpha、Beta和Gamma)振荡活动来扩展先前的研究；其次，评估SCZ患者在N-back任务中诱发的振荡活动、表现和临床症状之间的关系。与健康受试者相比，SCZ患者的额叶伽马振荡活动在3-Back状态下最为明显。与健康受试者相比，SCZ患者在所有WM负荷下的额叶β活动也被观察到降低。任务绩效与阴性症状呈负相关，与阳性症状无关。我们的发现表明，在西医期间诱发的额叶振荡活动在伽马和贝塔频段选择性地改变，这可能是SCZ患者西医损害的原因之一。这些发现可能对WM缺陷背后的病理生理学及其与阴性症状的关系提供重要的见解，并可能成为SCZ认知增强策略的潜在神经生物学标记物。(C)2010爱思唯尔B.V.保留所有权利。
Gamma (gamma) oscillations (30-50 Hz) elicited during working memory (WM) are altered in schizophrenia (SCZ). However, the nature of the relationship between evoked frontal oscillatory activity, WM performance and symptom severity has yet to be ascertained. This study had two objectives. First, to extend previous studies by examining delta, theta, alpha, beta, and gamma (delta, theta, alpha, beta, and gamma) oscillatory activities during the N-back task in SCZ patients compared to healthy subjects; second, to evaluate the relationship between oscillatory activities elicited during the N-back, performance, and clinical symptoms in SCZ patients. Patients with SCZ elicited excessive frontal gamma oscillatory activity that was most pronounced in the 3-back condition compared to healthy subjects. Reduced frontal beta activity at all WM loads was also observed in patients with SCZ compared to healthy subjects. Task performance was inversely correlated with negative symptoms but not with positive symptoms. Our findings suggest that evoked frontal oscillatory activities during WM are selectively altered in the gamma and beta frequency bands that may contribute to WM impairment in SCZ patients. These findings may provide important insights into the pathophysiology underlying WM deficits, its relationship to negative symptoms and may represent a potential neurobiological marker for cognitive enhancing strategies in SCZ. (C) 2010 Elsevier B.V. All rights reserved.