Characterization of the Inner and Outer Fiber Layers in the Developing Cerebral Cortex of Gyrencephalic Ferrets.
Characterization of the Inner and Outer Fiber Layers in the Developing Cerebral Cortex of Gyrencephalic Ferrets.
复制标题
环脑雪貂发育中的大脑皮层的内部和外部纤维层的特征。
DOI：
10.1093/cercor/bhy312
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Kawasaki H.
中科院分区：
文献类型：
--
作者：
Saito K;Mizuguchi K;Horiike T;Dinh Duong TA;Shinmyo Y;Kawasaki H.
哺乳动物大脑皮层在进化过程中的变化引起了人们的极大兴趣。与小鼠相比，雪貂、猴子和人类的大脑皮层更加发达。尽管这些动物皮质发育中的祖细胞特征已被深入研究，但纤维层的特征仍然很大程度上难以捉摸。通过利用我们的雪貂子宫内电穿孔技术，我们系统地研究了正在发育的雪貂皮层中轴突纤维的细胞起源和投影模式。我们发现，雪貂正在发育的大脑皮层有两层纤维层，就像猴子和人类的情况一样。内纤维层中的轴突纤维向对侧和皮质下投射，而外纤维层中的轴突纤维将轴突发送到邻近的皮质区域。此外，我们用小鼠进行了类似的实验，发现雪貂和小鼠之间有意想不到的相似之处。我们的结果揭示了哺乳动物大脑中的细胞起源、投射模式、发育过程和纤维层的进化。
Changes in the cerebral cortex of mammals during evolution have been of great interest. Ferrets, monkeys, and humans have more developed cerebral cortices compared with mice. Although the features of progenitors in the developing cortices of these animals have been intensively investigated, those of the fiber layers are still largely elusive. By taking the advantage of our in utero electroporation technique for ferrets, here we systematically investigated the cellular origins and projection patterns of axonal fibers in the developing ferret cortex. We found that ferrets have 2 fiber layers in the developing cerebral cortex, as is the case in monkeys and humans. Axonal fibers in the inner fiber layer projected contralaterally and subcortically, whereas those in the outer fiber layer sent axons to neighboring cortical areas. Furthermore, we performed similar experiments using mice and found unexpected similarities between ferrets and mice. Our results shed light on the cellular origins, the projection patterns, the developmental processes, and the evolution of fiber layers in mammalian brains.