Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model
Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model
复制标题
DOI：
10.1126/science.279.5349.377
复制
发表时间：
1998-01-16
期刊：
影响因子：
56.9
通讯作者：
Ruoslahti, E
中科院分区：
文献类型：
--
作者：
Arap, W;Pasqualini, R;Ruoslahti, E
使用噬菌体展示文库的体内选择来分离特异性靶向肿瘤血管的肽。当与抗癌药物阿霉素结合时，其中两种肽（一种含有α（v）整合素结合精氨酸-甘氨酸-天冬氨酸基序，另一种含有天冬酰胺-甘氨酸-精氨酸基序）增强了该药物对抗裸鼠人乳腺癌异种移植物的功效，并降低了其毒性。这些结果表明，开发基于肿瘤血管系统中受体选择性表达的靶向化疗策略是可能的。
In vivo selection of phage display libraries was used to isolate peptides that home specifically to tumor blood vessels. When coupled to the anticancer drug doxorubicin, two of these peptides-one containing an alpha(v) integrin-binding Arg-Gly-Asp motif and the other an Asn-Gly-Arg motif-enhanced the efficacy of the drug against human breast cancer xenografts in nude mice and also reduced its toxicity. These results indicate that it may be possible to develop targeted chemotherapy strategies that are based on selective expression of receptors in tumor vasculature.