Insufficient expression of the melanocortin-1 receptor by human dermal fibroblasts contributes to excess collagen synthesis in keloid scars
Insufficient expression of the melanocortin-1 receptor by human dermal fibroblasts contributes to excess collagen synthesis in keloid scars
复制标题
人真皮成纤维细胞的黑皮质素-1受体表达不足导致瘢痕疙瘩中胶原蛋白合成过多
DOI：
10.1111/exd.12250
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发表时间：
2013-11-01
影响因子：
3.6
通讯作者：
Lei, Tie-Chi
中科院分区：
文献类型：
--
作者：
Luo, Long-Fei;Shi, Ying;Lei, Tie-Chi
黑素细胞刺激激素（MSH）/黑素皮质素-1受体（MC 1 R）信号通路的激活除了促进色素生成外，还对皮肤炎症和纤维化反应产生拮抗作用。在此，使用一系列技术研究瘢痕疙瘩来源的成纤维细胞和瘢痕疙瘩瘢痕组织的MC 1 R表达。5种不同瘢痕疙瘩成纤维细胞系的MC 1 R mRNA表达水平与5种正常成纤维细胞系相比显著降低，不到一半（P
Activation of the -melanocyte-stimulating hormone (MSH)/melanocortin-1 receptor (MC1R) signalling pathway exerts antagonistic actions on cutaneous inflammatory and fibrogenic responses in addition to promoting pigment production. Herein, the expression of MC1R by keloid-derived fibroblasts and keloid scar tissue was investigated using a range of techniques. MC1R mRNA expression levels in five different keloid fibroblast cell lines were significantly reduced to less than half compared with five normal fibroblast cell lines (P