The Relationship Between Gray Matter Morphometry and Neuropsychological Performance in a Large Sample of Cognitively Healthy Adults
The Relationship Between Gray Matter Morphometry and Neuropsychological Performance in a Large Sample of Cognitively Healthy Adults
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DOI：
10.1007/s11682-007-9000-5
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发表时间：
2007-06-01
影响因子：
3.2
通讯作者：
Johnson, Sterling C.
中科院分区：
文献类型：
--
作者：
Newman, Lisa M.;Trivedi, Mehul A.;Johnson, Sterling C.
采用基于体素的形态测量法（VBM）对221名18 ~ 84岁认知健康的成年人的脑灰质（GM）体积与两种临床常用的额叶或执行功能神经心理学测量指标--连线测验B部分（TrailsB）和控制性口头词语联想测验（COWAT）的表现之间的关系进行了研究。我们假设这些措施将与在背外侧额叶的GM体积。使用基于体素的多元回归将认知功能与调制的GM概率图相关联，同时控制年龄、教育、性别和总颅内体积。双侧额下回外侧和左侧基底节与TrailsB存在相关性。在左侧额下回和额中回与COWAT存在相关性。损伤研究长期以来一直暗示这些区域对执行功能的重要性。目前的结果证实并扩展了这些先前的发现，以健康的成年人。
Voxel-based morphometry (VBM) was used to examine the relationship between gray matter (GM) volume and performance on two commonly used clinical neuropsychological measures of frontal lobe or executive function, the Trail Making Test part B (TrailsB) and the Controlled Oral Word Association Test (COWAT) in 221 cognitively healthy adults between the ages of 18 and 84. We hypothesized that these measures would be associated with GM volume in the dorsolateral frontal lobes. Voxel-based multiple regression was used to correlate cognitive function with modulated GM probability maps while controlling for age, education, gender, and total intracranial volume. A relationship with TrailsB was found in bilateral lateral inferior frontal gyri and left basal ganglia. A relationship with COWAT was found in the left lateral inferior and middle frontal gyri. Lesion studies have long implicated the importance of these regions for executive function. The present results confirm and extend those prior findings to healthy adults.