Association study between the pericentrin(PCNT) gene and schizophrenia
Association study between the pericentrin(PCNT) gene and schizophrenia
复制标题
中心周蛋白（PCNT）基因与精神分裂症的关联研究
DOI：
10.1007/s12017-009-8106-x
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Ohmori T
中科院分区：
文献类型：
--
作者：
Numata S;Nakataki M;Iga J;Tanahashi T;Nakadoi Y;Ohi K;Hashimoto R;Takeda M;Itakura M;Ueno S;Ohmori T
Disrupted-in-schizophrenia 1 (DISC1), a known genetic risk factor for schizophrenia (SZ) and major depressive disorder (MDD), interacts with several proteins and some of them are reported to be genetically associated with SZ. Pericentrin (PCNT) also interacts withDISC1and recently single-nucleotide polymorphisms (SNPs) within thePCNTgene have been found to show significant associations with SZ and MDD. In this study, case-controlled association analysis was performed to determine if thePCNTgene is implicated in SZ. Nine SNPs were analyzed in 1,477 individuals (726 patients with SZ and 751 healthy controls). No significant difference was observed between the controls and the patients in allelic frequencies or genotypic distributions of eight SNPs. Although allelic distribution of rs11702684 was different between the two groups (P= 0.042), the difference did not reach statistical significance after permutation correction for multiple comparisons. In the haplotypic analysis, we could not find any significant association in our subjects, either. This gene may not play a major role independently in the etiology of SZ in the Japanese population.
