Unexpected photo-instability of 2,6-sulfonamide-substituted BODIPYs and its application to development of caged GABA
Unexpected photo-instability of 2,6-sulfonamide-substituted BODIPYs and its application to development of caged GABA
复制标题
2,6-磺酰胺取代的 BODIPY 的意外光稳定性及其在笼式 GABA 开发中的应用
DOI：
10.1002/cbic.201600097
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发表时间：
2016
期刊：
影响因子：
3.2
通讯作者：
Yasuteru Urano
中科院分区：
文献类型：
--
作者：
Aoi Takeda;Toru Komatsu;Hiroshi Nomura;Naka Masamitsu;Norio Matsuki;Yuji Ikegaya;Takuya Terai;Tasuku Ueno;Kenjiro Hanaoka;Tetsuo Nagano;Yasuteru Urano
研究了2，6-磺酰胺取代的二吡咯亚硼(BODIPY)荧光团的意外光不稳定性，发现了伴随着多个键断裂的光反应。我们对光产物进行了表征，并利用光反应设计了笼式γ-氨基丁酸(GABA)衍生物，它可以在可见光范围(>；450 nm)下释放GABA。这使得我们能够刺激小鼠脑片中的神经细胞。
Investigation of the unexpected photo‐instability of 2,6‐sulfonamide‐substituted derivatives of the boron dipyrromethene (BODIPY) fluorophore led to the discovery of a photoreaction accompanied by multiple bond scissions. We characterized the photoproducts and utilized the photoreaction to design a caged γ‐aminobutyric acid (GABA) derivative that can release GABA upon irradiation in the visible range (>450 nm). This allowed us to stimulate neural cells in mouse brain slices.