Stressful life events in a clinical sample of depressed children in Hungary
Stressful life events in a clinical sample of depressed children in Hungary
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DOI：
10.1016/j.jad.2008.08.018
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发表时间：
2009-05-01
影响因子：
6.6
通讯作者：
Vetro, Agnes
中科院分区：
文献类型：
--
作者：
Mayer, Laszlo;Lopez-Duran, Nestor L.;Vetro, Agnes
背景资料：关于抑郁症儿科临床人群中压力性生活事件的特征以及性别、年龄及其相互作用可能影响生活事件与抑郁症关系的程度的信息有限。使用一个非常大的临床样本的儿童和青少年与重性抑郁症（MDD），因此，我们研究了生活事件以各种方式，以及他们的关系，以年龄和sex.Methods：该研究包括一个基于临床的样本434名儿童（7-14岁）与DSM-IV诊断的MDD和他们的母亲，和一个基于学校的比较样本724名儿童和他们的母亲。生活事件的信息从mothers.Results：儿童与抑郁症的一生压力事件的数量是对照组的两倍，具有非常高的压力源的7-9岁，在整个青春期稳定。相比之下，对照样本经历了逐渐增加的压力生活事件作为一个功能的年龄到青春期中期。父母健康事件、近亲死亡和家庭内事件与MDD诊断显著相关。在年幼儿童中，父母健康以及死亡事件集群与MDD诊断之间的关联性明显强于青少年。局限性：临床和比较样本之间的地理差异，以及可能的家长报告偏见可能会影响这些调查结果的普遍性。结论：一些紧张的生活事件和MDD之间的关联似乎是由年龄调节，强调需要检查特定的事件，以及集群的事件。更好地理解这种相互作用可能有助于早期识别儿童MDD的可能风险因素。(C)2008 Elsevier B. V.保留所有权利。
Background: There is limited information on the characteristics of stressful life events in depressed pediatric clinical populations and the extent to which sex, age, and their interactions may influence the relations of life events and depression. Using a very large clinical sample of children and adolescents with major depressive disorder (MDD), we therefore examined life events in various ways, as well as their relations to age and sex.Methods: The study included a clinic-based sample of 434 children (ages 7-14) with a DSM-IV diagnosis of MDD and their mothers, and a school-based comparison sample of 724 children and their mothers. Life event information was obtained from the mothers.Results: Children with MDD had twice the number of lifetime stressful events than did the comparison group, with very high levels of stressors by the age of 7-9 that stabilized across adolescence. In contrast, the comparison sample experienced a gradual increase in stressful life events as a function of age up to mid-adolescence. Parental health events, death of close relatives, and intrafamilial events were significantly associated with MDD diagnosis. There were significantly stronger associations between parental health-as well as death-event clusters and MDD diagnosis among younger children than adolescents. Limitations: Geographical differences between the clinical and comparison samples, as well as possible parental reporting biases may affect the generalizability of these findings.Conclusion: The association between some stressful life events and MDD seems to be moderated by age, underscoring the need to examine specific events, as well as clusters of events. Better understanding of such interactions may facilitate early identification of possible risk factors for pediatric MDD. (C) 2008 Elsevier B.V. All rights reserved.