Genome-wide association reveals the locus responsible for four-horned ruminant
Genome-wide association reveals the locus responsible for four-horned ruminant
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DOI：
10.1111/age.12409
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发表时间：
2016-04-01
期刊：
影响因子：
2.4
通讯作者：
Cockett, Noelle
中科院分区：
文献类型：
--
作者：
Kijas, James W.;Hadfield, Tracy;Cockett, Noelle
养殖大西洋鲑鱼（萨尔莫salar）是全球重要的生产物种，包括在澳大利亚，自20世纪60年代以来一直在进行育种和选择。SNP基因分型平台的最新发展意味着现在可以实施全基因组关联和基因组预测以加速遗传增益。作为一个先驱，本研究收集了基因型在218 132个单核苷酸多态性在777鱼从塔斯马尼亚繁殖人口的遗传多样性，连锁不平衡（LD）和插补准确性的强度进行评估。塔斯马尼亚大西洋鲑鱼的遗传多样性低于欧洲种群内观察到的使用四个多样性指标进行比较。等位基因频率的分布也显示出明显的差异，塔斯马尼亚动物携带过多的低次要等位基因频率变异。观察到的LD的强度在短距离内很高（
Farmed Atlantic salmon (Salmo salar) is a globally important production species, including in Australia where breeding and selection has been in progress since the 1960s. The recent development of SNP genotyping platforms means genome-wide association and genomic prediction can now be implemented to speed genetic gain. As a precursor, this study collected genotypes at 218 132 SNPs in 777 fish from a Tasmanian breeding population to assess levels of genetic diversity, the strength of linkage disequilibrium (LD) and imputation accuracy. Genetic diversity in Tasmanian Atlantic salmon was lower than observed within European populations when compared using four diversity metrics. The distribution of allele frequencies also showed a clear difference, with the Tasmanian animals carrying an excess of low minor allele frequency variants. The strength of observed LD was high at short distances (