Attenuation of stress-elicited brain catecholamines, serotonin and plasma corticosterone levels by calcined gold preparations used in Indian system of medicine.
Attenuation of stress-elicited brain catecholamines, serotonin and plasma corticosterone levels by calcined gold preparations used in Indian system of medicine.
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印度医学体系中使用的锻金制剂可降低应激引起的脑儿茶酚胺、血清素和血浆皮质酮水平。
DOI：
10.1111/j.1742-7843.2005.pto_10.x
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发表时间：
2005
影响因子：
3.1
通讯作者：
Vohora,ShashiBharat
中科院分区：
文献类型：
--
作者：
Shah,ZahoorAhmad;Gilani,RabiaAfzal;Sharma,Pragya;Vohora,ShashiBharat
与心理健康相关的问题在现代急剧增加。因此，应大力寻求有效和安全的替代办法。强制制动是大鼠中最佳探索的应激模型之一，皮质酮、5-羟色胺（5-HT）和儿茶酚胺（即去甲肾上腺素、肾上腺素、多巴胺）的作用已得到充分证明。本实验研究了两种金制剂（AyurvedicSwarnaBhasma和UnaniKushtaTilaKalan）在束缚应激1小时、2小时和4小时不同时间点的治疗潜力，在束缚应激前用两种金制剂AyurvedicSwarnaBhasma和UnaniKushtaTilaKalan（25 mg/kg，口服10天）预处理大鼠。脑儿茶酚胺，5-羟色胺和血浆皮质酮水平测定后1，2和4小时的约束应力，使用HPLC和血浆皮质酮使用发光分光光度法。金制剂使束缚应激诱导的脑儿茶酚胺（去甲肾上腺素、肾上腺素和多巴胺）、5-HT和血浆皮质酮水平升高恢复至接近正常水平。黄金，广泛用于现代医学治疗类风湿性关节炎，在印度医学系统的各种药用价值很高。传统的黄金制剂具有滋补/恢复活力和抗氧化特性。我们早期的研究发现，有趣的镇痛，免疫刺激，适应性和糖原节约这些制剂的属性，但他们在压力和抑郁症的影响还没有被调查。显着的恢复改变值接近正常水平表明黄金制剂的压力和抑郁症的潜力。
Problems associated with mental health have increased tremendously in modern times. The search for effective and safe alternatives should, therefore, be persued vigourously. Forced immobilization is one of the best explored models of stress in rats and the role of corticosterone, serotonin (5‐HT) and catecholamines, i.e. norepinephrine, epinephrine, dopamine is well documented. We investigated the therapeutic potential of two gold preparations (AyurvedicSwarna Bhasmaand UnaniKushta Tila Kalan) in restraint induced stress at different time points of 1 hr, 2 hr and 4 hr. We pretreated rats with two gold prepaprations, AyurvedicSwarna Bhasmaand UnaniKushta Tila Kalan(25 mg/kg, orally for 10 days) prior to restraint stress. Brain catecholamine, serotonin and plasma corticosterone levels were determined following 1, 2 and 4 hr restraint stress, using HPLC and also plasma corticosterone using luminescence spectrophotometry. Gold preparations restored restraint stress‐induced elevation in levels of brain catecholamines (norepinephrine, epinephrine and dopmine), 5‐HT and plasma corticosterone to near normal levels. Gold, widely used in modern medicine for the treatment of rheumatoid arthritis, is highly valued for various medicinal uses in Indian systems of medicine. Traditional gold preparations are attributed with tonic/rejuvenating and antioxidant properties. Our earlier studies revealed interesting analgesic, immunostimulant, adaptogenic and glycogen sparing properties in these preparations, but their effects in stress and depression have not been investigated yet. Significant restoration of altered values to near normal levels suggest potentials for gold preparations in stress and depression.