Transcription and promoter usage of the myc gene in normal somatic and spermatogenic cells.
Transcription and promoter usage of the myc gene in normal somatic and spermatogenic cells.
复制标题
DOI：
10.1126/science.6494906
复制
发表时间：
1984-11
期刊：
影响因子：
56.9
通讯作者：
T. Stewart;A. Bellvé;P. Leder
中科院分区：
文献类型：
--
作者：
T. Stewart;A. Bellvé;P. Leder
在体细胞中，myc的转录水平并不局限于特定的细胞类型，而是与细胞分裂的速率密切相关。这种转录涉及使用两个活性myc启动子，并产生两种信使RNA，它们在不同组织的转录本中有差异。与体细胞形成明显对比的是，有丝分裂和减数分裂的生殖细胞具有非常少的myc转录物，并且似乎在没有myc转录的情况下增殖，至少有几次分裂。这些结果提出了有趣的问题，myc基因产物在终末分化细胞中的作用，特别是生殖系系列。
In somatic cells the level of myc transcription is not restricted to particular cell types but correlates closely with the rate of cell division. Such transcription involves the use of two active myc promoters and produces two messenger RNA species that are differentially represented among the transcripts of different tissues. In apparent contrast to somatic cells, mitotically and meiotically dividing germ cells have very few myc transcripts and appear to proliferate, at least for a few divisions, in the absence of myc transcription. These results raise interesting questions regarding the role of the myc gene product in terminally differentiating cells, particularly of the germ line series.