Predictors of leptin concentration and association with cardiovascular risk in patients with coronary artery disease: results from the AtheroGene study
Predictors of leptin concentration and association with cardiovascular risk in patients with coronary artery disease: results from the AtheroGene study
复制标题
DOI：
10.3109/1354750x.2015.1130745
复制
发表时间：
2017-05-01
期刊：
影响因子：
2.6
通讯作者：
Westermann, Dirk
中科院分区：
文献类型：
--
作者：
Bickel, Christoph;Schnabel, Renate B.;Westermann, Dirk
背景：瘦素在白色脂肪组织中产生，但也在人类冠状动脉粥样硬化病变中产生。目的：本研究的目的是评估瘦素对确诊冠状动脉疾病 (CAD) 患者的预后价值 (N=1907)。方法：AtheroGene 是一项当代 CAD 队列研究 (N=3229)。中位随访时间为 3.8 年（四分位 1/3 与 2.8/4.9）年。结果：对于女性的完全调整模型 HR=1.32，瘦素浓度与风险比 (HR) 相关，但在男性中并不显着。在 167 名患者中观察到终点心血管死亡和非致命性心肌梗死。结论：在已知 CAD 的女性中，瘦素浓度升高有助于预测心血管死亡和非致命性心肌梗死。
Context: Leptin is produced in white adipose tissue, but also in human coronary atherosclerotic lesions.Objective: The aim of this study is to assess the prognostic value of leptin in patients with proven coronary artery disease (CAD) (N=1907).Methods: AtheroGene is a contemporary CAD cohort study (N=3229). Median follow-up time was 3.8 (Quartile 1/3 with 2.8/4.9) years.Results: Leptin concentration was associated with a hazard ratio (HR) for the fully adjusted model of HR=1.32 in women but was not significant in men. The endpoint cardiovascular death and non-fatal myocardial infarction was observed in 167 patients.Conclusion: In women with known CAD, increased leptin concentration is useful for predicting cardiovascular death and non-fatal myocardial infarction.