Enhanced ion utilization efficiency using an electrodynamic ion funnel trap as an injection mechanism for ion mobility spectrometry
Enhanced ion utilization efficiency using an electrodynamic ion funnel trap as an injection mechanism for ion mobility spectrometry
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DOI：
10.1021/ac701648p
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发表时间：
2008-02-01
影响因子：
7.4
通讯作者：
Smith, Richard D.
中科院分区：
文献类型：
--
作者：
Clowers, Brian H.;Ibrahim, Yehia M.;Smith, Richard D.
从连续源采样离子包的常规离子迁移谱仪传统上受到固有的低占空比的限制。因此，离子利用效率被限制在< 1%，以保持仪器的分辨能力。使用改进的电动离子漏斗，我们证明了与离子迁移谱（IMS）结合的积累，存储和喷射离子的能力，这提高了从离子漏斗阱（IFT）喷射的离子包的电荷密度，并提供了相当大的增加IMS仪器的整体离子利用效率。通过比较连续离子束电流与使用法拉第板的IFT-IMS实验中的脉冲离子电流的幅度，揭示了信号强度的7倍增加。此外，我们描述了，IFT的操作特性，使用飞行时间质谱仪连接到IMS漂移管。
Conventional ion mobility spectrometers that sample ion packets from continuous sources have traditionally been constrained by an inherently low duty cycle. As such, ion utilization efficiencies have been limited to < 1% in order to maintain instrumental resolving power. Using a modified electrodynamic ion funnel, we demonstrated the ability to accumulate, store, and eject ions in conjunction with ion mobility spectrometry (IMS), which elevated the charge density of the ion packets ejected from the ion funnel trap (IFT) and provided a considerable increase in the overall ion utilization efficiency of the IMS instrument. A 7-fold increase in signal intensity was revealed by comparing continuous ion beam current with the amplitude of the pulsed ion current in IFT-IMS experiments using a Faraday plate. Additionally, we describe the, IFT operating characteristics using a time-of-flight mass spectrometer attached to the IMS drift tube.