Nandrolone abuse decreases anxiety and impairs memory in rats via central androgenic receptors.
Nandrolone abuse decreases anxiety and impairs memory in rats via central androgenic receptors.
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诺龙滥用可通过中枢雄激素受体减轻大鼠的焦虑并损害记忆。
DOI：
10.1017/s1461145708008754
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
M. Kraus
中科院分区：
文献类型：
--
作者：
D. Kouvelas;C. Pourzitaki;G. Papazisis;T. Dagklis;Konstantinos Dimou;M. Kraus
合成代谢雄激素类固醇（AAS）影响中枢神经系统的区域，这些区域涉及情感和认知反应，如性，焦虑和记忆。在本研究中，我们模仿滥用AAS通过给药大剂量的AAS癸酸诺龙（ND）的大鼠。此后，大鼠暴露于高架十字迷宫和嗅觉社会记忆测试，以评估其焦虑样和认知行为。为了揭示ND引起的这些情绪和认知变化是否是通过直接激活大脑中的雄激素受体（AR）引起的，将AR拮抗剂氟替卡松（FL）脑室内（i. c. v.）给药。雄性大鼠随机分为4组，ND组皮下注射ND 15 mg/kg，每日1次，共6 wk;第二组在ND基础上，每日静脉注射FL 5 μ g，共6 wk（ND+FL组）。第三组大鼠仅接受FL，对照组注射溶媒。与对照组相比，ND组在迷宫测试中花费了更多的时间来研究张开的手臂，并在嗅觉社会记忆测试中识别少年。ND+FL组大鼠的情绪行为和认知能力与对照组相似。单独注射FL不影响焦虑或记忆。这些结果表明，重复，高剂量的ND管理减少焦虑和损害记忆的大鼠通过直接激活中央AR。
Anabolic androgenic steroids (AASs) affect areas of the central nervous system, which are involved in emotional and cognitive responses such as sexuality, anxiety, and memory. In the present study we imitated the abuse of AASs by administering high doses of the AAS nandrolone decanoate (ND) to rats. Thereafter rats were exposed to an elevated plus-maze and an olfactory social memory test to evaluate their anxiety-like and cognitive behaviour. To reveal whether these emotional and cognitive changes evoked by ND were caused via direct activation of androgenic receptors (ARs) in the brain, the AR antagonist flutamide (FL) was administered intracerebroventricularly (i.c.v.). Male rats were randomly divided in four groups, one group received 15 mg/kg ND subcutaneously, once daily for 6 wk (ND group). In the second group, in addition to ND, a daily dose of 5 microg FL was injected i.c.v. also for 6 wk (ND+FL group). The third group of rats received only FL and in the control group the vehicle was injected. The ND group clearly spent more time investigating the open arms in the maze test and recognizing the juvenile during the olfactory social memory test in comparison to the control group. In the ND+FL group rats showed similar emotional behaviour and cognitive ability to that of the control group. Injection of FL alone did not affect either anxiety or memory. These results indicate that repeated, high-dose administration of ND decreases anxiety and impairs memory in rats via direct activation of central ARs.
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DOI：
10.1016/b978-0-12-571138-8.50007-x
发表时间：
1982
期刊：
Recent progress in hormone research
影响因子：
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作者：
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DOI：
10.1210/endo.138.2.4937
发表时间：
1997
期刊：
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影响因子：
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作者：
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影响因子：
2.9
作者：
Ahima,RS;Harlan,RE
通讯作者：
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DOI：
10.1080/15287390903489422
发表时间：
2010
期刊：
Journal of toxicology and environmental health. Part A
影响因子：
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作者：
Rushton EK;Jiang J;Leonard SS;Eberly S;Castranova V;Biswas P;Elder A;Han X;Gelein R;Finkelstein J;Oberdörster G
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Oberdörster G