Learned movements elicited by direct stimulation of cerebellar mossy fiber afferents
Learned movements elicited by direct stimulation of cerebellar mossy fiber afferents
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DOI：
10.1016/s0896-6273(00)80831-4
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发表时间：
1999-09-01
期刊：
影响因子：
16.2
通讯作者：
Ivarsson, M
中科院分区：
文献类型：
--
作者：
Hesslow, G;Svensson, P;Ivarsson, M
经典条件反射中的条件刺激（CS）是通过苔藓纤维系统到达小脑的。去大脑雪貂接受成对的前肢和眼周刺激，直到它们对前肢刺激做出眨眼反应。当直接刺激苔藓纤维时，动物立即做出条件反射性眨眼反应，也就是说，没有经过苔藓纤维刺激的训练。逆向：通过用木质素阻断刺激部位腹侧的苔藓纤维来防止激活。可以排除小脑输出作为CS的功能。分析表明，条件反射（CR）不是由苔藓纤维侧支深核。因此，记忆痕迹可能位于小脑皮层。
Definitive evidence is presented that the conditioned stimulus (CS) in classical conditioning reaches the cerebellum via the mossy fiber system. Decerebrate ferrets received paired forelimb and periocular stimulation until they responded with blinks to the forelimb stimulus. When direct mossy fiber stimulation was then given, the animals responded with conditioned blinks immediately, that is, without ever having been trained to the mossy fiber stimulation. Antidromic: activation was prevented by blocking mossy fibers with lignocaine ventral to the stimulation site. It could be excluded that cerebellar output functioned as the CS. Analysis of latencies suggests that conditioned responses (CRs) are not generated by mossy fiber collaterals to the deep nuclei. Hence, the memory trace is probably located in the cerebellar cortex.