Microdamage in bone: Implications for fracture, repair, remodeling, and adaptation
Microdamage in bone: Implications for fracture, repair, remodeling, and adaptation
复制标题
DOI：
10.1615/critrevbiomedeng.v34.i3.20
复制
发表时间：
2006-01-01
影响因子：
--
通讯作者：
Galley, Sarah A.
中科院分区：
文献类型：
--
作者：
Donahue, Seth W.;Galley, Sarah A.
疲劳微损伤在骨骼中积累是生理负荷的结果。损伤多表现为微裂纹，长度一般为50 ~ 100 μ m。这些类型的裂缝发生在骨间质，经常发生在骨水泥线附近。体外实验表明，疲劳损伤的积累降低了骨的材料性能（例如，弹性模量）。疲劳损伤的积累与应力性骨折和脆性骨折的病因有关。然而，骨骼具有显著的检测和修复疲劳微损伤的能力。本文综述了骨中不同类型微损伤的鉴定与定量实验技术、骨中不同部位的体内微裂纹密度、微损伤对骨材料性能的影响、微损伤在骨折中的作用以及疲劳微损伤检测与修复的生物学机制。
Fatigue microdamage accumulates in bone as a result of physiological loading. The damage is often manifested as microcracks, which are typically 50-100 mu m long. These types of cracks develop in the interstitial bone and frequently abut osteon cement lines. In vitro experimentation has shown that an accumulation of fatigue damage reduces the material properties of bone (e.g., elastic modulus). An accumulation of fatigue damage has been implicated in the etiology of stress fractures and fragility fractures. However, bone has a remarkable ability to detect and repair fatigue microdamage. This article reviews the experimental techniques for identifying and quantifying different types of microdamage in bone, the density of in vivo microcracks at different skeletal locations, the effect of microdamage on bone material properties, the role of microdamage in bone fracture, and the biological mechanisms for the detection and repair of fatigue microdamage.