Preferential localization of IgG memory B cells adjacent to contracted germinal centers
Preferential localization of IgG memory B cells adjacent to contracted germinal centers
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DOI：
10.1073/pnas.1005443107
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发表时间：
2010-07-06
影响因子：
11.1
通讯作者：
Kurosaki, Tomohiro
中科院分区：
文献类型：
--
作者：
Aiba, Yuichi;Kometani, Kohei;Kurosaki, Tomohiro
长期以来，人们一直认为，记忆B细胞离开生殖中心（GC）后，定居在边缘区或加入再循环池。在这里，我们证明了硝基酚-鸡γ-球蛋白诱导的CD 38（+）IgG 1（+）记忆B细胞优先定位于脾脏中收缩的GC附近。二次免疫后，该区域的记忆B细胞增殖，这种反应被CD 4（+）T细胞的耗竭所消除。我们还发现这些IgG 1（+）记忆B细胞可以在其表面呈递抗原，并且这种活性是其激活所必需的。这些结果暗示了GC周围区域是记忆B细胞存活和再活化的重要部位。
It has long been presumed that after leaving the germinal centers (GCs), memory B cells colonize the marginal zone or join the recirculating pool. Here we demonstrate the preferential localization of nitrophenol-chicken gamma-globulin-induced CD38(+)IgG1(+) memory B cells adjacent to contracted GCs in the spleen. The memory B cells in this region proliferated after secondary immunization, a response that was abolished by depletion of CD4(+) T cells. We also found that these IgG1(+) memory B cells could present antigen on their surface, and that this activity was required for their activation. These results implicate this peri-GC region as an important site for survival and reactivation of memory B cells.