Helicobacter pylori prevalence in diabetes mellitus patients with dyspeptic symptoms and its relationship to glycemic control and late complications
Helicobacter pylori prevalence in diabetes mellitus patients with dyspeptic symptoms and its relationship to glycemic control and late complications
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DOI：
10.1007/s10620-007-0185-7
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发表时间：
2008-10-01
影响因子：
3.1
通讯作者：
Yilmaz, Ugur
中科院分区：
文献类型：
--
作者：
Demir, Mehmet;Gokturk, Huseyin Savas;Yilmaz, Ugur
背景：关于幽门螺杆菌的流行及其与糖尿病晚期并发症的关系，目前有相互矛盾的报道。本研究的目的是确定H。pylori感染与2型糖尿病的关系。幽门螺杆菌感染与血糖控制、晚期并发症。材料与方法：141例2型糖尿病患者和142例非糖尿病患者均伴有上消化道症状。所有患者均行上消化道内镜检查，取胃窦和胃体活检标本。H.通过快速尿素酶试验和组织病理学检查评估每个患者的幽门螺杆菌状态。所有受试者均进行血糖、HbA 1c、24 h尿微量白蛋白、神经肌电图和眼底镜检查。结果H. pylori感染在2型糖尿病患者和非糖尿病对照组中分别为61.7%和58.5%，无统计学意义（P = 0.577）。糖尿病病程、空腹血糖和血红蛋白A1 c水平、肾病和视网膜病变的患病率在两组（糖尿病患者与非糖尿病患者）之间没有显著差异。60.3%的2型糖尿病患者无晚期并发症，而糖尿病患者至少有一种晚期并发症。在统计学上，H。幽门螺杆菌感染和神经病变的存在（P = 0.021）。结论H.幽门螺杆菌感染在糖尿病患者和非糖尿病对照组之间没有显著差异。有趣的是，H. pylori感染有较高的神经病变发生率，尽管糖尿病、视网膜病变、肾病和H.幽门螺杆菌状态。
Background There are contradictory reports on Helicobacter pylori prevalence and its relationship to late complications of diabetes mellitus (DM). The aim of this study was to determine the prevalence of H. pylori infection in type 2 DM patients and to evaluate the relationship between H. pylori infection and the glycemic control, late complications. Material and Method A total of 141 type 2 DM patients and 142 nondiabetic subjects with upper gastrointestinal symptoms were enrolled in the study. All patients underwent upper gastrointestinal endoscopy with biopsy specimens obtained from gastric antrum and corpus. H. pylori status was evaluated in each patient by both the rapid urease test and histopathological examination. Plasma glucose, HbA1c, microalbuminuria in 24 h collected urine, electroneuromyography, and fundoscopic examinations were performed in all subjects. Results The prevalence of H. pylori infection was 61.7% and 58.5%, respectively, among type 2 diabetic patients and nondiabetic controls and was not statistically significant (P = 0.577). The duration of diabetes, fasting blood glucose and haemoglobin A1c levels, nephropathy and retinopathy prevalence did not differ significantly between the two groups (diabetics versus nondiabetics). There was no late complication in 60.3% of the type 2 diabetic patients as compared to at least one late complication in the remainders. A statistically significant correlation was found between H. pylori infection and the presence of neuropathy (P = 0.021). Conclusions The prevalence of H. pylori infection did not differ significantly between the diabetic patients and nondiabetic controls. Interestingly, diabetics with H. pylori infection had a higher incidence of neuropathy, although there was no association between the duration and regulation of diabetes, retinopathy, nephropathy and H. pylori status.