NAD(P)H oxidases and their relevance to atherosclerosis
NAD(P)H oxidases and their relevance to atherosclerosis
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DOI：
10.1016/s1050-1738(01)00097-4
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发表时间：
2001-04-01
影响因子：
9.3
通讯作者：
Griendling, KK
中科院分区：
文献类型：
--
作者：
Sorescu, D;Szöcs, K;Griendling, KK
在过去十年中进行的研究已经确定了非吞噬性血管细胞特有的NAD（P）H氧化酶。从这些酶释放的活性氧调节基本的细胞功能，如生长（增生性或肥大性）、内皮功能障碍、迁移和炎症，其已被证明在动脉粥样硬化形成中起作用。来自实验动物和人类研究的证据暗示非吞噬细胞NAD（P）H氧化酶在动脉粥样硬化形成的多个方面，表明这些酶可能是血管疾病过程的重要决定因素。(C)2001年，Elsevier Science Inc.
Studies performed during the last decade have identified NAD(P)H oxidases unique to nonphagocytic vascular cells. The reactive oxygen species released from these enzymes regulate fundamental cellular functions such as growth (hyperplastic or hypertrophic), endothelial dysfunction, migration and inflammation, which have been demonstrated to play a role iii atherogenesis. Evidence from experimental animal and human studies implicate the nonphagocytic NAD(P)H oxidases in multiple aspects of atherogenesis, suggesting that these enzymes may be important determinants of the course of vascular disease. (C) 2001, Elsevier Science Inc.