Plasma fatty acid composition is associated with the metabolic syndrome and low-grade inflammation in overweight adolescents
Plasma fatty acid composition is associated with the metabolic syndrome and low-grade inflammation in overweight adolescents
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DOI：
10.1093/ajcn/82.6.1178
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发表时间：
2005-12-01
影响因子：
7.1
通讯作者：
Simon, C
中科院分区：
文献类型：
--
作者：
Klein-Platat, C;Drai, J;Simon, C
背景资料：与肥胖一起，血浆脂肪酸（FA）组成可以调节代谢综合征（MS）的发展。目的：我们的目的是研究青少年血浆磷脂和胆固醇酯（CE）中FA组成与体重状况、MS和炎症的关系。设计：采用气相色谱法测定了120名12岁青少年（60名正常体重和60名超重）血浆FA组成。我们还测量了MS的存在，胰岛素抵抗与稳态模型评估，和白细胞介素6和C-反应蛋白浓度的青少年。结果：MS存在于25%的超重青少年，但没有在正常体重的青少年。与超重青少年相比，正常体重青少年的磷脂中饱和脂肪酸（SFA）含量较低（P <0.001），磷脂中二十二碳六烯酸含量较高（P < 0.001）。在超重受试者中，FA成分与MS特征相关，与体脂无关。磷脂中多不饱和脂肪酸（PUFA）与脂肪酸（SFA）比值（PUFA：SFA）增加0.1时，MS的比值比为0.91（P = 0.03），CE为0.90（P = 0.06）。磷脂中PUFA：SFA和亚油酸与HDL胆固醇呈正相关（均P < 0.01）。磷脂和CE中的PUFA：SFA与IL-6呈负相关（均P < 0.05）。磷脂中的二十碳五烯酸（P = 0.06）和胆固醇酯中的二十碳五烯酸（P < 0.05）以及胆固醇酯中的亚麻酸（P < 0.05）与C反应蛋白呈负相关。在调整腰臀比后，这些关系仍然显著。FA组成和稳态模型assessment.Conclusions之间没有显着关系：血浆FA组成与健康青少年的体重状况。高摄入长链多不饱和脂肪酸，特别是n-3多不饱和脂肪酸，可以保护肥胖受试者早在青春期就免受MS和低度炎症的影响。
Background: Together with adiposity, plasma fatty acid (FA) composition can modulate the development of the metabolic syndrome (MS).Objective: Our aim was to investigate the relations of FA composition in plasma phospholipids and cholesterol esters (CEs) with weight status, MS, and inflammation in adolescents.Design: Plasma FA composition was measured by gas-liquid chromatography in 120 (60 normal-weight and 60 overweight) 12-y-old adolescents. We also measured the presence of MS, insulin resistance with the homeostasis model assessment, and interleukin 6 and C-reactive protein concentrations in the adolescents.Results: MS was present in 25% of the overweight adolescents but in none of the normal-weight adolescents. Compared with overweight adolescents, normal-weight adolescents had lower saturated FAs (SFAs) in both phospholipids (P < 0.001) and CEs (P < 0.01) and higher docosahexaenoic acid in phospholipids (P < 0.001). In overweight subjects, FA composition was associated with MS features independent of body fat. The odds ratios of MS for a 0.1 increase in the ratio of polyunsaturated FAs (PUFA) to SFAs (PUFA:SFA) were 0.91 in phospholipids (P = 0.03) and 0.90 in CEs (P = 0.06). In phospholipids, PUFA:SFA and linoleic acid were associated positively with HDL cholesterol (P < 0.01 for both). PUFA:SFA in phospholipids and CEs were associated inversely with interleukin 6 (P < 0.05 for both). Eicosapentaenoic acid in phospholipids (P = 0.06) and CEs (P < 0.05) and linolenic acid in CEs (P < 0.05) were inversely related to C-reactive protein. These relations remained significant after adjustment for the waist-to-hip ratio. No significant relation between FA composition and the homeostasis model assessment was observed.Conclusions: Plasma FA composition is associated with weight status in healthy adolescents. High intake of long-chain PUFAs, especially n-3 PUFAs, may protect obese subjects against MS and low-grade inflammation as early as adolescence.