The natural anticoagulant protein S is decreased in male smokers.
The natural anticoagulant protein S is decreased in male smokers.
复制标题
男性吸烟者的天然抗凝蛋白 S 减少。
DOI：
10.1016/0002-8703(91)90761-6
复制
发表时间：
1991
影响因子：
4.8
通讯作者：
Comp,PC
中科院分区：
文献类型：
--
作者：
Scott,BD;Esmon,CT;Comp,PC
蛋白S是一种天然的抗凝血浆蛋白;家族性缺乏与血栓并发症有关。由于吸烟会增加心肌梗死和中风的风险，我们研究了吸烟男性的蛋白S系统。在血浆中，游离蛋白S具有功能活性，与C4 b结合蛋白结合的蛋白S无活性。男性吸烟者（n= 24）的总蛋白S低于非吸烟者（n= 24）（16.8 ± 4.3 μg/ml vs 19.8 ± 5.1 μg/ml，p< 0.02）。吸烟者的C4 b结合蛋白水平较高（p< 0.05）（212 ± 47 μg/ml vs 186 ± 52 μg/ml）。吸烟者的游离蛋白S显著较低（6.9 ± 2.3 μg/ml vs 8.0 ± 1.9 μg/ml，p= 0.02）。蛋白S的这些改变可能导致与吸烟相关的血栓性并发症。
Protein S is a natural anticoagulant plasma protein; familial deficiency is associated with thrombotic complications. Since smoking carries an increased risk of myocardial infarction and stroke, we investigated the protein S system of men who smoke. In plasma, free protein S is functionally active and protein S bound to C4b binding protein is inactive. Male smokers (n= 24) have lower total protein S than nonsmokers (n= 24) (16.8 ± 4.3 μg/ml versus 19.8 ± 5.1 μg/ml,p< 0.02). C4b binding protein levels are higher (p< 0.05) in smokers (212 ± 47 μg/ml versus 186 ± 52 μg/ml). Free protein S is significantly lower in smokers (6.9 ± 2.3 μg/ml versus 8.0 ± 1.9 μg/ml,p= 0.02). These alterations in protein S may contribute to the thrombotic complications associated with smoking.