Type 1 diabetes incidence and prevalence trends in a cohort of Canadian children and youth
Type 1 diabetes incidence and prevalence trends in a cohort of Canadian children and youth
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DOI：
10.1111/pedi.12566
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发表时间：
2018-05-01
影响因子：
3.4
通讯作者：
Amed, Shazhan
中科院分区：
文献类型：
--
作者：
Fox, Danya A.;Islam, Nazrul;Amed, Shazhan
背景与目的：1型糖尿病的发病率长期以来在全球范围内呈上升趋势，然而，越来越多的证据表明其上升速度可能正在放缓。本研究的目的是描述加拿大儿童和青少年样本中1型糖尿病的发病率和流行趋势。方法：使用关联的管理数据集和经过验证的糖尿病病例发现定义提取病例。使用JoinPoint回归分析程序分析发病率和患病率趋势。结果：在2002-2003年至2012-2013年的11年期间，观察到1型糖尿病的发病率略有增加。每年的事件总数由2005-2006年的201宗至2007-2008年的250宗不等。每年流行病例总数为1790例（2002-2003年）至2264例（2012-2013年）。发病率在5至14岁儿童中最高，在最小（1-4岁）和最大（15-19岁）年龄组中最低。发病率增加最显著的是10至14岁的儿童。在整个研究期间，年龄标准化患病率显著增加。结论：这些结果与美国的数据相似，但在发病率的年变化百分比以及特定年龄的发病率趋势方面与欧洲的数据不同。与1型糖尿病相关的低死亡率保持一致，患病率继续上升。
Background and Objective: Incidence rates of type 1 diabetes have long been on the rise across the globe, however, there is emerging evidence that the rate of rise may be slowing. The objective of this study was to describe trends in the incidence and prevalence of type 1 diabetes in a sample of Canadian children and youth.Methods: Cases were extracted using linked administrative datasets and a validated diabetes case-finding definition. Incidence and prevalence trends were analyzed using the JoinPoint regression analysis program.Results: A small increase in the incidence of type 1 diabetes was observed over the 11-year period from 2002-2003 to 2012-2013. Total incident cases per year ranged from 201 (2005-2006) to 250 (2007-2008). Total prevalent cases per year ranged from 1790 (2002-2003) to 2264 (2012-2013). Incidence was highest among children aged 5 to 14 years, and lowest in the youngest (1-4 years) and oldest (15-19 years) age brackets. The most significant increase in incidence was in children aged 10 to 14 years. Age-standardized prevalence increased significantly throughout the study period.Conclusion: These results are similar to data from the United States but differ from European data with respect to the annual percent change for incidence as well as age-specific incidence trends. In keeping with the low mortality rates associated with type 1 diabetes, the prevalence continues to rise.