Omental graft improves functional recovery of transected peripheral nerve
Omental graft improves functional recovery of transected peripheral nerve
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DOI：
10.1002/mus.10229
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发表时间：
2002-10-01
期刊：
影响因子：
3.4
通讯作者：
Kinne, RKH
中科院分区：
文献类型：
--
作者：
Castañeda, F;Kinne, RKH
大网膜具有多种有利于神经元萌发和方向的特性。因此，我们分析了使用大网膜移植物桥接神经缺损横断大鼠坐骨神经后的功能恢复。在第 1 组中，产生了 25-30 毫米的神经缺损并用大网膜移植物桥接，而在第 2 组中，进行了端到端修复。每隔 2 周评估一次坐骨功能指数 (SFI)，直至术后 8 周。第 1 组的功能恢复速度快于第 2 组。8 周后，第 1 组的 SFI 从 -100% 显着改善至 -45% (+/- -4%) (P < 0.001)，而第 2 组的 SFI 显着改善，从 -72% +/- -2% (n = 10) 改善。在组织学上，与端到端修复相比，大网膜移植物包含更多新发育的神经纤维和更少的疤痕组织。因此，大网膜移植似乎可以改善再生轴突芽的定向生长，并且可能是治疗周围神经损伤的一种手段。 (C) 2002 年 Wiley 期刊公司
The omentum has several properties that are advantageous for neuronal sprouting and direction. We have therefore analyzed functional recovery following transection of rat sciatic nerve using omental graft to bridge the nerve defect. In group 1, a 25-30-mm nerve defect was produced and bridged with omental graft, whereas in group 2, an end-to-end repair was performed. The sciatic function index (SFI) was assessed at 2-week intervals until 8 weeks after surgery. Functional recovery was faster in group 1 than in group 2. After 8 weeks, SFI was improved significantly from -100% to -45% (+/- -4%) in group 1 (P < 0.001) compared to -72% +/- -2% in group 2 (n = 10). Histologically, the omental graft contained more newly developed nerve fibers and less scar tissue than the end-to-end repair. Thus, omental graft appears to improve directional growth of regenerating axon sprouts and may be a means of treating peripheral nerve injury. (C) 2002 Wiley Periodicals, Inc.