Evaluation of the inflammatory infiltrate in pouchitis with 111In-labeled granulocytes.
Evaluation of the inflammatory infiltrate in pouchitis with 111In-labeled granulocytes.
复制标题
用 111In 标记的粒细胞评估储袋炎的炎症浸润。
DOI：
10.1016/0016-5085(93)90264-d
复制
发表时间：
1993
期刊：
影响因子：
29.4
通讯作者：
M. Keighley
中科院分区：
文献类型：
--
作者：
W. Kmiot;S. Hesslewood;N. Smith;H. Thompson;L. K. Harding;M. Keighley
背景：本研究的目的是阐明甲硝唑治疗后膀胱炎的炎性浸润性改变。方法：27例患者接受了功能分级、乙状结肠镜和组织学评分、111In标记的粒细胞扫描，以及4d的粪便标本进行111In标记的粒细胞排泄。结果：膀胱炎的大体炎症分级(乙状结肠镜评分)与急性组织学评分(P<；0.0001)、慢性组织学评分(P<；0.001)、4小时111In扫描(P<；0.001)、24小时111In扫描(P<；0.001)、4天排泄物111In排泄量(P<；0.001)有良好的相关性。甲硝唑治疗后乙状结肠镜下和24小时扫描的炎症分级明显降低，4天粪便111粒细胞排泄量减少。结论：甲硝唑治疗后膀胱炎的炎性渗出为急性或慢性，以中性粒细胞为特征，多局限于膀胱粘膜，甲硝唑治疗后可见炎性渗出减少。
Background:The aim of this study was to elucidate the inflammatory infiltrate in pouchitis and define the changes following metronidazole therapy.Methods:Twenty-seven patients underwent functional grading, sigmoidoscopic and histological scoring,111In-labeled granulocyte scanning, and 4-day fecal collections for111In-labeled granulocyte excretion. Six of the patients with pouchitis underwent repeat studies after 1-month treatment with metronidazole, 400 mg three times daily.Results:The grade of macroscopic inflammation in the pouch mucosa (sigmoidoscopic score) correlated well with the acute histological score (P<0.0001), chronic histological score (P< 0.001), 4-hour111In scan (P< 0.001), 24-hour111In scan (P< 0.001), and with 4-day fecal111In excretion (P< 0.001). After metronidazole therapy there was decreased inflammatory grade sigmoidoscopically and histologically on the 4- and 24-hour scans and decreased 4-day fecal111In granulocyte excretion.Conclusions:This study confirms that the inflammatory infiltrate in pouchitis is acute or chronic, is characterized by neutrophils, is usually localized to pouch mucosa, and is always decreased after metronidazole therapy.