CXCL10 Is a Circulating Inflammatory Marker in Patients with Advanced Heart Failure: a Pilot Study
CXCL10 Is a Circulating Inflammatory Marker in Patients with Advanced Heart Failure: a Pilot Study
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DOI：
10.1007/s12265-016-9703-3
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发表时间：
2016-08-01
影响因子：
3.4
通讯作者：
Blankesteijn, W. Matthijs
中科院分区：
文献类型：
--
作者：
Altara, Raffaele;Manca, Marco;Blankesteijn, W. Matthijs
趋化因子参与心脏重塑；然而，它们作为心力衰竭生物标志物的意义尚不清楚。我们观察到心力衰竭大鼠心肌梗死后1周循环中的CXCR3受体趋化因子CXCL9和CXCL10升高。CXCL10在远心区和梗死区也升高，16周时仍升高，远心区1周时CXCL9升高。在人类中，等级聚类和主成分分析表明，循环中的CXCL10、MIP-1α和CD40配体是区分健康和心力衰竭受试者的最佳指标。根据NYHA分类II至IV，症状性心力衰竭患者的血清CXCL10水平升高。在晚期心力衰竭患者中，CXCL10、MIP-1α和CD40配体的存在似乎是主要的。这些发现确定了心力衰竭患者中不同的炎性介质的特征。
Chemokines are involved in the remodeling of the heart; however, their significance as biomarkers in heart failure is unknown. We observed that circulating CXCR3 receptor chemokines CXCL9 and CXCL10 in a rat model of heart failure were increased 1 week after myocardial infarction. CXCL10 was also increased in both remote and infarcted regions of the heart and remained elevated at 16 weeks; CXCL9 was elevated in the remote area at 1 week. In humans, hierarchical clustering and principal component analysis revealed that circulating CXCL10, MIP-1 alpha, and CD40 ligand were the best indicators for differentiating healthy and heart failure subjects. Serum CXCL10 levels were increased in patients with symptomatic heart failure as indexed by NYHA classification II through IV. The presence of CXCL10, MIP-1 alpha, and CD40 ligand appears to be dominant in patients with advanced heart failure. These findings identify a distinct profile of inflammatory mediators in heart failure patients.