Prooxidant-antioxidant balance as a new risk factor in patients with angiographically defined coronary artery disease
Prooxidant-antioxidant balance as a new risk factor in patients with angiographically defined coronary artery disease
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DOI：
10.1016/j.clinbiochem.2007.12.008
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发表时间：
2008-04-01
影响因子：
2.8
通讯作者：
Koliakos, George
中科院分区：
文献类型：
--
作者：
Alamdari, Daryoush Hamidi;Ghayour-Mobarhan, Majid;Koliakos, George
目的：通过改良的促氧化剂-抗氧化剂平衡（PAB）测定法测定血管造影定义的冠状动脉疾病（CAD+）患者的促氧化剂-抗氧化剂平衡（PAB），并将PAB值作为新的心血管危险因素。设计和方法：对于61名CAD+患者和63名健康志愿者，测量PAB并确定其与人类学和临床参数的相关性。结果：与对照组相比，在患者中观察到PAB值显著增加。血管造影结果（病变血管数量）与患者的PAB值之间存在相关性，但不太显著。PAB值与收缩压、舒张压、吸烟、空腹血糖、血清尿素浓度呈显著正相关，与血清肌酐、胆红素呈显著负相关。需要进一步的临床研究来证实PAB值作为心血管风险因素的效力。(c)2008年加拿大临床化学家协会。爱思唯尔公司出版All rights reserved.
Objectives: Determination of the prooxidant-antioxidant balance (PAB) in patients with angiographically defined coronary artery disease (CAD+) by a modified PAB assay and presentation of PAB value as a novel cardiovascular risk factor.Design and methods: For 61 patients with CAD+ and 63 healthy volunteers, the PAB were measured and its correlation was determined with anthropological and clinical parameters.Results: A significant increase of the PAB value was observed in patients in comparison to control group. A correlation, which is not quite significant, was noted between angiographic finding (number of diseased vessel) and the PAB values in patients. A significant positive correlation was established between the PAB value and systolic blood pressure, diastolic blood pressure, smoking, fasting blood sugar and serum urea concentration; and a significant negative correlation was established between PAB value and serum creatinine and bilirubin.Conclusions: This study shows that the PAB value may be considered as a cardiovascular risk factor. Further clinical research is needed to substantiate the potency of the PAB value as a cardiovascular risk factor. (c) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.