Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control
Estimating the Respective Contributions of Human and Viral Genetic Variation to HIV Control
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DOI：
10.1371/journal.pcbi.1005339
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发表时间：
2017-02-01
影响因子：
4.3
通讯作者：
Fellay, Jacques
中科院分区：
文献类型：
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作者：
Bartha, Istvan;McLaren, Paul J.;Fellay, Jacques
我们评估了部分的变化，HIV-1设定点病毒载量归因于病毒或人类遗传因素，通过使用联合主机/病原体的遗传数据，从541个HIV感染者。我们发现，病毒遗传多样性解释了29%的病毒载量变化，而宿主因素解释了8.4%。使用一个联合模型，包括主机和病毒的影响，我们估计总共30%的遗传力，表明大多数主机的影响反映在病毒序列变异。
We evaluated the fraction of variation in HIV-1 set point viral load attributable to viral or human genetic factors by using joint host/pathogen genetic data from 541 HIV infected individuals. We show that viral genetic diversity explains 29% of the variation in viral load while host factors explain 8.4%. Using a joint model including both host and viral effects, we estimate a total of 30% heritability, indicating that most of the host effects are reflected in viral sequence variation.