Application of advanced brain positron emission tomography-based molecular imaging for a biological framework in neurodegenerative proteinopathies
Application of advanced brain positron emission tomography-based molecular imaging for a biological framework in neurodegenerative proteinopathies
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DOI：
10.1016/j.dadm.2019.02.004
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发表时间：
2019-12-01
影响因子：
5.3
通讯作者：
Jacobs, Andreas H.
中科院分区：
文献类型：
--
作者：
Perani, Daniela;Iaccarino, Leonardo;Jacobs, Andreas H.
前言神经退行性疾病从基于临床的分类到基于病理学的分类的快速转变正在出现，这在很大程度上是由成像生物标记物的增加推动的。由欧盟联合计划-神经退行性疾病研究2016年资助的创新多示踪分子脑成像框架，旨在为现有的和新的分子成像技术在痴呆症中的应用提供路线图。方法我们考虑采用基于病理学的框架来使用和开发正电子发射断层扫描技术的当前和未来影响。结果这种方法将加强对阿尔茨海默病和其他痴呆的多因素病因的理解。讨论病理生物标记物的可用性将很快改变临床和研究实践。重要的是，全面了解这些技术的优点和注意事项将促进知情使用以充分利用这些工具。
Introduction A rapid transition from a clinical-based classification to a pathology-based classification of neurodegenerative conditions, largely promoted by the increasing availability of imaging biomarkers, is emerging. The Framework for Innovative Multi-tracer molecular Brain Imaging, funded by the EU Joint Program - Neurodegenerative Disease Research 2016 "Working Groups for Harmonisation and Alignment in Brain Imaging Methods for Neurodegeneration," aimed at providing a roadmap for the applications of established and new molecular imaging techniques in dementia.Methods We consider current and future implications of adopting a pathology-based framework for the use and development of positron emission tomography techniques.ResultsThis approach will enhance efforts to understand the multifactorial etiology of Alzheimer's disease and other dementias.Discussion The availability of pathology biomarkers will soon transform clinical and research practice. Crucially, a comprehensive understanding of strengths and caveats of these techniques will promote an informed use to take full advantage of these tools.