ABNORMALITIES OF B-CELL ACTIVATION AND IMMUNOREGULATION IN PATIENTS WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME
ABNORMALITIES OF B-CELL ACTIVATION AND IMMUNOREGULATION IN PATIENTS WITH THE ACQUIRED IMMUNODEFICIENCY SYNDROME
复制标题
DOI：
10.1056/nejm198308253090803
复制
发表时间：
1983-01-01
影响因子：
158.5
通讯作者：
FAUCI, AS
中科院分区：
文献类型：
--
作者：
LANE, HC;MASUR, H;FAUCI, AS
本文对12例男性同性恋获得性免疫缺陷综合征患者、5例健康男性同性恋者和12例异性恋对照者的B淋巴细胞功能进行了研究。与异性恋对照组相比，患者自发分泌IG的细胞数量增加，B细胞对T细胞非依赖性B细胞有丝分裂原的增殖反应降低，辅助性T细胞质量缺陷。自发性高活性B细胞反应和对T细胞非依赖性B细胞活化信号的不应性高度提示B细胞的体内多克隆活化，并可能是这些患者中观察到的B细胞高反应性表现（如高丙种球蛋白血症）的原因。获得性免疫缺陷综合征中免疫功能障碍的范围显然涉及B细胞和T细胞。
B lymphocyte function was studied in 12 homosexual male patients with the acquired immunodeficiency syndrome, 5 healthy homosexual men and 12 heterosexual controls. In comparison with the heterosexual controls, the patients had elevated numbers of cells spontaneously secreting Ig, decreased B cell proliferative responses to T cell-independent B cell mitogens, and qualitatively deficient helper T cells. The hyperacitve spontaneous B cell responses and the refractoriness to signals for T cell-independent B cell activation were highly suggestive of an in vivo polyclonal activation of B cells and may have been responsible for the manifestations of B cell hyperreactivity, such as hypergammaglobulinemia, seen in these patients. The scope of immune dysfunction in the acquired immunodeficiency syndrome apparently involves B cells and T cells.