Pretreatment with empty liposomes attenuates the immunopathology of invasive pulmonary aspergillosis in corticosteroid-immunosuppressed mice
Pretreatment with empty liposomes attenuates the immunopathology of invasive pulmonary aspergillosis in corticosteroid-immunosuppressed mice
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DOI：
10.1128/aac.01268-06
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发表时间：
2007-03-01
影响因子：
4.9
通讯作者：
Kontoyiannis, Dimitrios P.
中科院分区：
文献类型：
--
作者：
Lewis, Russell E.;Chamilos, Georgios;Kontoyiannis, Dimitrios P.
在侵袭性肺曲霉病的非血小板减少小鼠模型中，用空脂质体（E-lipo）预处理与10 mg/kg体重脂质体阿替霉素B几乎一样有效，并且上级1 mg/kg阿替霉素B脱氧胆酸盐。E-lipo的有益免疫调节特性似乎可以弥补其缺乏直接抗真菌活性。
In a nonneutropenic murine model of invasive pulmonary aspergillosis, pretreatment with empty liposomes (E-lipo) was nearly as effective as 10 mg/kg of body weight liposomal amphotericin B and superior to I mg/kg amphotericin B deoxycholate. The beneficial immunomodulatory properties of E-lipo appear to compensate for their lack of direct antifungal activity.