RELIABILITY OF RATES OF GLUCOSE APPEARANCE INVIVO CALCULATED FROM CONSTANT TRACER INFUSIONS
RELIABILITY OF RATES OF GLUCOSE APPEARANCE INVIVO CALCULATED FROM CONSTANT TRACER INFUSIONS
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DOI：
10.1042/bj1720407
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发表时间：
1978-01-01
影响因子：
4.1
通讯作者：
BURKE, JF
中科院分区：
文献类型：
--
作者：
ALLSOP, JR;WOLFE, RR;BURKE, JF
根据示踪剂数据计算未标记葡萄糖的出现率，并将其与手术去除所有内源性葡萄糖产生来源的麻醉犬中未标记葡萄糖的实际输注率进行比较。根据平衡比放射性计算的未标记葡萄糖的平均稳态出现率（0.3%）不显著高于未标记葡萄糖的实际输注速率（n = 6）。在非稳态期间，葡萄糖的时变分布容积（V）对于根据Steele描述的池依赖性方程正确预测未标记葡萄糖的出现率是必要的[（1959）Ann.N.Y. Acad. Sci. 82，420-430]。通过使用40 ml/kg的V固定值，可以合理地预测葡萄糖出现率的快速波动，但使用更大的V固定值（100- 160 ml/kg），葡萄糖出现率的波动是不准确的。Issekutz，Issekutz & Elahi [（1974）Can.《生理药理学杂志》52，215-224]合理准确地预测了葡萄糖输注速率的单步增加，但Steele（1959）方程在预测未标记葡萄糖输注速率的连续变化方面更好。
The rate of appearance of unlabelled glucose was calculated from tracer data and compared with the actual rate of infusion of unlabelled glucose into a anaesthetized dog with all sources of endogenous glucose production surgically removed. The mean steady-state rate of appearance of unlabelled glucose calculated from the equilibrium specific radioactivity was insignificantly higher (0.3%) than the actual rate of infusion of unlabelled glucose (n = 6). During non-steady states, a time-variable volume of distribution of glucose (V) was necessary to predict the rate of appearance of unlabelled glucose correctly from the pool-dependent equation described by Steele [(1959) Ann. N.Y. Acad. Sci. 82, 420–430]. Rapid fluctuations in the rate of appearance of glucose could be predicted reasonably well by using a fixed value of V for 40ml/kg, but by using larger fixed values for V (100–160ml/kg) the rates were inaccurate. The pool-dependent two-radiactive-isotope technique described by Issekutz, Issekutz & Elahi [(1974) Can. J. Physiol. Pharmacol. 52, 215–224] predicted single-step increases in the rate of infusion of glucose reasonably accurately, but the Steele (1959) equation was better at predicting sequential changes in the rate of infusion of unlabelled glucose.