THE USE OF METRONIDAZOLE, TINIDAZOLE AND DIMETRIDAZOLE IN ELIMINATING TRICHOMONADS FROM LABORATORY MICE
THE USE OF METRONIDAZOLE, TINIDAZOLE AND DIMETRIDAZOLE IN ELIMINATING TRICHOMONADS FROM LABORATORY MICE
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DOI：
10.1258/002367788780746287
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发表时间：
1988-10-01
影响因子：
2.4
通讯作者：
OLSON, ME
中科院分区：
文献类型：
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作者：
ROACH, PD;WALLIS, PM;OLSON, ME
将甲硝唑、替硝唑和二甲硝咪唑在饮用水中给予实验感染鼠三毛滴虫和微小四毛滴虫的小鼠数天。小鼠成功感染T. muris和T.从受感染的沙鼠身上发现了微孢子虫。用含2.5mg/ml甲硝唑或替硝唑的1%蔗糖溶液灌胃小鼠，成功地消除了滴虫感染。接受1.0 mg/ml甲硝唑、1.0 mg/ml替硝唑和1.2、5.0和10.0 mg/ml二甲硝咪唑的小鼠未能消除毛滴虫。仅在接受10 mg/ml二甲硝咪唑的小鼠中观察到饮水量减少。在只接受1%蔗糖的小鼠中，感染没有消除。
Metronidazole, tinidazole and dimetridazole were administered in the drinking water for days to mice experimentally infected with Tritrichomonas muris and Tetratrichomonas microta. Mice were successfully infected with T. muris and T. microta recovered from infected gerbils. The trichomonas infection was successfully elminated in mice given a 1% sucrose solution containing 2.5 mg/ml metronidazole or tinidazole. Mice receiving 1.0 mg/ml metronidazole, 1.0 mg/ml tinidazole and 1.2, 5.0 and 10.0 mg/ml dimetridazole failed to eliminate the trichomonas organism. A reduction in water intake was only noted with mice receiving 10 mg/ml dimetridazole. In mice receiving only 1% sucrose the infection was not eliminated.