Soluble Tag-Assisted Peptide Head-to-Tail Cyclization: Total Synthesis of Mahafacyclin B
Soluble Tag-Assisted Peptide Head-to-Tail Cyclization: Total Synthesis of Mahafacyclin B
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DOI：
10.1021/ol4003477
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发表时间：
2013-03-15
期刊：
影响因子：
5.2
通讯作者：
Chiba, Kazuhiro
中科院分区：
文献类型：
--
作者：
Fujita, Yuko;Fujita, Shuji;Chiba, Kazuhiro
A soluble tag-assisted liquid-phase method was successfully applied to peptide head-to-tail cyclization, leading to the total synthesis of antimalarial cyclic heptapeptide, mahafacyclin B (1). The cyclization was carried out in the liquid phase with the tag remaining, which allowed rapid reaction workup and product isolation.
