Occupational and environmental risk factors for chronic rhinosinusitis in China: a multicentre cross-sectional study.
Occupational and environmental risk factors for chronic rhinosinusitis in China: a multicentre cross-sectional study.
复制标题
中国慢性鼻窦炎的职业和环境危险因素：多中心横断面研究
DOI：
10.1186/s12931-016-0366-z
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发表时间：
2016-05-17
影响因子：
5.8
通讯作者：
Fu QL
中科院分区：
文献类型：
--
作者：
Gao WX;Ou CQ;Fang SB;Sun YQ;Zhang H;Cheng L;Wang YJ;Zhu DD;Lv W;Liu SX;Li PZ;Xu G;Shi J;Fu QL
背景慢性鼻窦炎 (CRS) 被定义为鼻旁窦粘膜持续超过 12 周的炎症状况。我们之前报道过，中国 CRS 的患病率约为 8%。在这里，我们旨在调查与CRS相关的职业和环境风险因素。方法收集了中国七个城市的数据：乌鲁木齐、长春、北京、武汉、成都、淮安和广州。 CRS 是根据欧洲鼻窦炎和鼻息肉立场文件 (EP3OS) 文件诊断的。参与者被要求填写一份标准化调查问卷，该调查问卷由全球过敏和哮喘欧洲网络 (GA2LEN) 项目开发，涵盖社会人口特征、慢性鼻窦炎相关症状以及职业和环境暴露。我们使用比值比 (OR) 和 95% 置信区间 (95% CI) 评估了 CRS 与各种职业和环境因素之间的关联。结果 总研究人群由 10,633 名受试者组成，其中 850 名 (7.99%) 根据 EP3OS 标准被定义为患有 CRS。我们发现职业和环境因素与 CRS 之间存在显着关联。具体来说，从事与清关相关的工作、职业性接触粉尘、职业性接触有毒气体、家里有宠物、家中或工作场所的地毯都是 CRS 的危险因素。此外，患有和未患有CRS的受试者在冬季保暖方法、夏季使用空调的时间以及暴露于发霉或潮湿环境的频率之间存在显着差异。结论我们的数据显示，一些职业和环境暴露与CRS密切相关，这有助于了解CRS的流行病学。
BackgroundChronic rhinosinusitis (CRS) is defined as a condition of inflammation in the paranasal sinus mucosa persisting for more than 12 weeks. We previously reported that the prevalence of CRS was about 8 % in China. Here, we aim to investigate the occupational and environmental risk factors associated with CRS.MethodsData were collected from seven Chinese cities: Urumqi, Changchun, Beijing, Wuhan, Chengdu, Huaian and Guangzhou. CRS was diagnosed according to the European Position Paper on Rhinosinusitis and Nasal Polyps (EP3OS) document. Participants were asked to complete a standardized questionnaire, which was developed by the Global Allergy and Asthma European Network (GA2LEN) project and covered sociodemographic characteristics, CRS-related symptoms and occupational and environmental exposures. We evaluated the association between CRS and various occupational and environmental factors using odds ratios (ORs) and 95 % confidence intervals (95 % CIs).ResultsThe total study population consisted of 10,633 subjects, 850 (7.99 %) of whom were defined as having CRS according to the EP3OS criteria. We found that there were significant associations between occupational and environmental factors and CRS. Specifically, having a clearance-related job, occupational exposure to dust, occupational exposure to poisonous gas, a pet at home or carpet at home or at the workplace were risk factors for CRS. Additionally, the method used to keep warm in winter, the duration of time spent using air conditioning in summer and the frequency of exposure to mouldy or damp environments were significantly different in subjects with and without CRS.ConclusionsOur data showed that some occupational and environmental exposures are strongly associated with CRS, which aids in understanding the epidemiology of CRS.