COVID-19 and Kawasaki Disease: Novel Virus and Novel Case.
COVID-19 and Kawasaki Disease: Novel Virus and Novel Case.
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DOI：
10.1542/hpeds.2020-0123
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发表时间：
2020-06-01
影响因子：
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通讯作者：
Mathew, Roshni
中科院分区：
文献类型：
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作者：
Jones, Veena G;Mills, Marcos;Mathew, Roshni
在2019冠状病毒病（COVID-19）大流行期间，我们看到广泛的疾病负担影响到地球仪所有年龄段的患者。然而，临床医生、流行病学家和研究人员都在努力描述和描述疾病过程，同时在第一线照顾患者，因此还有很多问题有待理解。我们描述了一名6个月大婴儿的病例，该婴儿入院并被诊断患有典型的川崎病，在发烧和轻微呼吸道症状的情况下，他的COVID-19筛查也呈阳性。患者按照治疗指南接受静脉注射免疫球蛋白和高剂量阿司匹林治疗，随后退热，临床症状消退。患者的初始超声心动图正常，在完成静脉注射免疫球蛋白输注后48小时内出院，并指示从COVID-19检测结果阳性之日起在家隔离14天。需要进一步研究小儿COVID-19的临床表现及其与川崎的潜在关联，以及发热婴儿COVID-19检测的适应症。
In the midst of the coronavirus disease 2019 (COVID-19) pandemic, we are seeing widespread disease burden affecting patients of all ages across the globe. However, much remains to be understood as clinicians, epidemiologists, and researchers alike are working to describe and characterize the disease process while caring for patients at the frontlines. We describe the case of a 6-month-old infant admitted and diagnosed with classic Kawasaki disease, who also screened positive for COVID-19 in the setting of fever and minimal respiratory symptoms. The patient was treated per treatment guidelines, with intravenous immunoglobulin and high-dose aspirin, and subsequently defervesced with resolution of her clinical symptoms. The patient's initial echocardiogram was normal, and she was discharged within 48 hours of completion of her intravenous immunoglobulin infusion, with instruction to quarantine at home for 14 days from the date of her positive test results for COVID-19. Further study of the clinical presentation of pediatric COVID-19 and the potential association with Kawasaki disease is warranted, as are the indications for COVID-19 testing in the febrile infant.