Depression Is More Common in Girls With Nonatopic Asthma
Depression Is More Common in Girls With Nonatopic Asthma
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DOI：
10.1378/chest.11-0219
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发表时间：
2011-11-01
期刊：
影响因子：
9.6
通讯作者：
Kozyrskyj, Anita L.
中科院分区：
文献类型：
--
作者：
Bahreinian, Salina;Ball, Geoff D. C.;Kozyrskyj, Anita L.
背景：哮喘可能增加儿童抑郁障碍共病的风险。患有哮喘或抑郁症的儿童往往超重。我们研究了是否抑郁症更可能在儿童特应性和非特应性哮喘，独立的腹部adiposity.Methods：横断面分析收集的数据进行研究哮喘，基因和环境在加拿大。由儿科过敏症专科医生对11至14岁的儿童进行评估，以确认哮喘、过敏性鼻炎和特应性皮炎的诊断。特应性哮喘的定义基于皮肤点刺试验，过敏性哮喘的定义基于除哮喘外还存在过敏性鼻炎或特应性皮炎。使用儿童抑郁量表简表评估抑郁症状。数据进行了分析，采用逻辑回归模型，以确定抑郁症的可能性，哮喘儿童，分层按性别和种族，腰围（WC），和atopy.Results调整：四百三十一名儿童年龄在11至14岁（136哮喘和295无哮喘）进行了研究。校正协变量后，与健康女孩相比，患有非特应性或非过敏性哮喘的女孩患抑郁症状的可能性高3倍（OR，2.84; 95%CI，1.00-8.10; OR，3.47; 95%CI，1.30-9.25）。女孩的腰围每增加10厘米，我们的模型显示抑郁症的几率增加39%至56%。在男孩，无论是哮喘，也没有WC表现出与depression.Conclusions：我们建议所有的健康从业者谁看到女孩哮喘或女孩谁是超重的手表抑郁症状和治疗共病抑郁症严重。胸部2011; 140（5）：1138-1145
Background: Asthma may increase the risk of comorbid depressive disorders in children. Children suffering from asthma or depression are more often overweight. We examined whether depression was more likely in children with atopic and nonatopic asthma, independent of abdominal adiposity.Methods: A cross-sectional analysis was performed on data collected in the Study of Asthma, Genes, and Environment in Canada. Children aged 11 to 14 years were assessed by a pediatric allergist to confirm asthma, allergic rhinitis, and atopic dermatitis diagnosis. Atopic asthma was defined based on skin prick testing and allergic asthma based on the presence of allergic rhinitis or atopic dermatitis in addition to asthma. Depressive symptoms were assessed using the Children's Depression Inventor-Short Form. Data were analyzed using logistic regression modeling to determine likelihood of depression in children with asthma, stratified by gender and adjusting for ethnicity, waist circumference (WC), and atopy.Results: Four hundred thirty-one children aged 11 to 14 years (136 with asthma and 295 without asthma) were studied. After adjusting for the covariates, girls who had nonatopic or nonallergic asthma were three times more likely to have comorbid depressive symptoms compared with healthy girls (OR, 2.84; 95% CI, 1.00-8.10; OR, 3.47; 95% CI, 1.30-9.25, respectively). For each 10-cm increase in WC of girls, our model showed a 39% to 56% increase in the chance of depression. In boys, neither asthma nor WC showed an association with depression.Conclusions: We recommend all health practitioners who see girls with asthma or girls who are overweight watch for depressive symptoms and treat comorbid depression seriously. CHEST 2011; 140(5):1138-1145