Sirtuin-3 (SIRT3) and the Hallmarks of Cancer.
Sirtuin-3 (SIRT3) and the Hallmarks of Cancer.
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DOI：
10.1177/1947601913486351
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发表时间：
2013-03-01
期刊：
影响因子：
--
通讯作者：
Kapila, Yvonne L
中科院分区：
文献类型：
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作者：
Alhazzazi, Turki Y;Kamarajan, Pachiyappan;Kapila, Yvonne L
Sirtuins(SIRT1-SIRT7)是酿酒酵母中沉默的信息调节因子2(Sir2)的哺乳动物同源物，由于其在癌症生物学和其他年龄相关疾病中的新作用，在过去的十年中一直是科学界研究的主要焦点。这一独特的酶家族的新兴功能包括在基因组稳定、血管生成、新陈代谢和失巢凋亡中的作用。在这里，我们回顾了sirtuins在癌症中作用的最新进展，特别是SIRT3及其在癌症特征中的作用，以及作为癌症治疗的潜在药物靶点的作用。
Sirtuins (SIRT1-SIRT7), the mammalian homologs of the silent information regulator 2 (Sir2) in Saccharomyces cerevisiae, have been a major focus of study in the scientific community this past decade because of their emerging role in cancer biology and other age-related diseases. Emerging functions for this unique family of enzymes include roles in genomic stability, angiogenesis, metabolism, and anoikis. Here, we review recent developments on the role of sirtuins in cancer with a particular focus on SIRT3 and its role in the hallmarks of cancer and as a potential drug target for cancer treatment.