Two new dihydrobenzofuran-type neolignans from Breynia fruticosa
Two new dihydrobenzofuran-type neolignans from Breynia fruticosa
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DOI：
10.1016/j.phytol.2013.03.009
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发表时间：
2013-05
影响因子：
1.7
通讯作者：
Yanping Li;Liao-Bin Dong;Duo-Zhi Chen;Hong-mei Li;Jin-dong Zhong;Fei Li;Xing Liu;Bei Wang
中科院分区：
文献类型：
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作者：
Yanping Li;Liao-Bin Dong;Duo-Zhi Chen;Hong-mei Li;Jin-dong Zhong;Fei Li;Xing Liu;Bei Wang
(7S，8R，7′S)-9，7′，9′-Trihydroxy-3，4-methylenedioxy-3′-methoxy[7-O-4‘，8-5’]新木脂素(1)和(7S，8R，7′S)-9，9′-dihydroxy-3，4-methylenedioxy-3′，7′-dimethoxy[7-O-4‘，8-5’]新木脂素(2)，以及9，9‘-二羟基-3，4-亚甲二氧基-3’-甲氧基[7-O-4‘，8-5‘]新木脂素(3)和(-)-双烯二醇(4)是从蒲公英全草中分离得到的。通过光谱方法和圆二色谱(CD)技术确定了化合物1和2的结构，包括绝对构型。通过对其对溴苯甲酸酯(4a)的OR谱、OR谱和ECD谱的计算，确定了4的绝对构型。
(7S,8R,7′S)-9,7′,9′-Trihydroxy-3,4-methylenedioxy-3′-methoxy [7-O-4′,8-5′] neolignan (1) and (7S,8R,7′S)-9,9′-dihydroxy-3,4-methylenedioxy-3′,7′-dimethoxy [7-O-4′,8-5′] neolignan (2), two new natural dihydrobenzofuran-type neolignans, along with 9,9′-dihydroxy-3,4-methylenedioxy-3′-methoxy [7-O-4′,8-5′] neolignan (3) and (-)-machicendiol (4), were isolated from the whole plants of Breynia fruticosa. The structures of 1 and 2, including the absolute configurations, were determined by spectroscopic methods and circular dichroism (CD) techniques. The absolute configuration of 4 was confirmed by calculations of the OR spectrum, together with OR and ECD spectra of its p-bromobenzoate ester (4a).