ROLE OF VITAMIN-E IN PREVENTING THE OXIDATION OF LOW-DENSITY-LIPOPROTEIN
ROLE OF VITAMIN-E IN PREVENTING THE OXIDATION OF LOW-DENSITY-LIPOPROTEIN
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DOI：
10.1093/ajcn/53.1.314s
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发表时间：
1991-01-01
影响因子：
7.1
通讯作者：
WAEG, G
中科院分区：
文献类型：
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作者：
ESTERBAUER, H;DIEBERROTHENEDER, M;WAEG, G
对来自不同供体的低密度脂蛋白的脂肪酸组成、抗氧化剂和抗氧化性进行了测定。在体外，低密度脂蛋白的抗氧化性由铜离子诱导氧化的滞后阶段的持续时间确定，与低密度脂蛋白的α-生育酚含量无关。补充维生素E后，低密度脂蛋白的α-生育酚含量可增加约9~30个摩尔/摩尔低密度脂蛋白，其抗氧化能力也随着α-生育酚含量的增加而几乎呈线性增加。结果表明，α-生育酚是决定低密度脂蛋白抗氧化能力的重要参数，但不是唯一的参数。
The fatty acid composition, antioxidants, and the oxidation resistance of the low-density lipoproteins (LDL) from a number of different donors were determined. The oxidation resistance of LDL, as determined in vitro by the duration of the lag-phase in copper ion-induced oxidation, did not correlate with the alpha-tocopherol content of the LDL. By supplementating plasma with vitamin E, the alpha-tocopherol content of LDL could be increased for approximately 9 to 30 mol/mol LDL and also the oxidative resistance increased nearly linearly with increasing alpha-tocopherol content. The results indicate that alpha-tocopherol is an important, yet not the only parameter that determines the oxidation resistance of LDL.