4D Flow CMR in Assessment of Valve-Related Ascending Aortic Disease
4D Flow CMR in Assessment of Valve-Related Ascending Aortic Disease
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DOI：
10.1016/j.jcmg.2011.05.004
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发表时间：
2011-07-01
影响因子：
14
通讯作者：
Higgins, Charles B.
中科院分区：
文献类型：
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作者：
Hope, Michael D.;Hope, Thomas A.;Higgins, Charles B.
采用 3 维时间分辨相位对比心脏磁共振（4 维 [4D]Flow）的血流成像是一种创新且具有视觉吸引力的心血管疾病研究方法，可以量化重要的次要血管参数，包括壁剪切应力。这项试点研究的假设是，4D Flow 将成为表征主动脉瓣相关血流动力学关系的有力工具，尤其是二叶主动脉瓣 (BAV) 和升主动脉 (AsAo) 扩张进展的关系。我们确定了之前使用 4D Flow 研究的 46 名患者：没有瓣膜疾病的三尖瓣主动脉瓣患者 (n = 20)，以及具有正常血流 (n = 7) 或偏心收缩射流导致异常右旋螺旋 AsAo 血流的 BAV 患者 (n = 19)。发现患有 BAV 和偏心收缩 AsAo 血流的患者亚组具有显着且不对称的壁剪切应力升高。这种增加的血流动力学负担可能使他们面临 AsAo 动脉瘤的风险。 (J Am Coll Cardiol Img 2011;4:781-7) (C) 2011 年，美国心脏病学会基金会
Blood flow imaging with 3-dimensional time-resolved, phase-contrast cardiac magnetic resonance (4-dimensional [4D]Flow) is an innovative and visually appealing method for studying cardiovascular disease that allows quantification of important secondary vascular parameters including wall shear stress. The hypothesis of this pilot study is that 4D Flow will become a powerful tool for characterizing the relationship of aortic valve-related flow dynamics, especially with bicuspid aortic valve (BAV), and progression of ascending aortic (AsAo) dilation. We identified 46 patients previously studied with 4D Flow: tricuspid aortic valve patients without valvular disease (n = 20), and BAV patients with either normal flow (n = 7) or eccentric systolic jets resulting in abnormal right-handed helical AsAo flow (n = 19). The subgroup of patients with BAV and eccentric systolic AsAo blood flow was found to have significantly and asymmetrically elevated wall shear stress. This increased hemodynamic burden may place them at risk for AsAo aneurysm. (J Am Coll Cardiol Img 2011;4:781-7) (C) 2011 by the American College of Cardiology Foundation