The flaws of laser Doppler in negative-pressure wound therapy research
The flaws of laser Doppler in negative-pressure wound therapy research
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DOI：
10.1111/wrr.12168
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发表时间：
2014-05-01
影响因子：
2.9
通讯作者：
Kahn, Delawir
中科院分区：
文献类型：
--
作者：
Kairinos, Nicolas;McKune, Andrew;Kahn, Delawir
最近的研究，使用激光多普勒以外的方式，表明负压伤口治疗（NPWT）期间的灌注减少，与世界文献相反。本研究的目的是评价激光多普勒的测量技术是否会受到NPWT敷料的压缩性质的影响，以及这是否可以解释相互矛盾的结果。在12个NPWT敷料上测试了一个假设，即激光多普勒可能记录到与NPWT期间仅通过手动压缩组织获得的读数相似的读数，每个敷料都经历了一系列交替的手动压缩力和NPWT（-125 mmHg）。在NPWT期间（n=12），5个实验的平均灌注记录增加，6个实验减少，1个实验保持不变。在此期间，当手动压力施加（n=12），有一个平均增加灌注在六个实验和减少。在12项实验中的10项中，NPWT和手动压力的灌注变化类型（增加或减少）相同。总之，当组织被压缩时，激光多普勒可能会错误地记录灌注增加，这意味着它在NPWT研究领域存在缺陷，因为组织总是在一定程度上被NPWT敷料压缩。
Recent studies, using modalities other than laser Doppler, have indicated that perfusion during negative-pressure wound therapy (NPWT) is reduced, contrary to world literature. The aim of the present study was to evaluate whether the measuring technique of the laser Doppler could be influenced by the compressive nature of NPWT dressings and whether this could explain the conflicting findings. A hypothesis that it may be possible for laser Doppler to record similar readings to those obtained during NPWT by merely compressing tissues manually was tested on 12 NPWT dressings, with each undergoing an alternating series of manual compressive forces and NPWT (-125mmHg). During the periods of NPWT (n=12), the mean perfusion recording increased in five experiments, reduced in six, and remained unchanged in one. During the period when manual pressure was applied (n=12), there was a mean increase in perfusion in six experiments and a reduction in six. The type of change in perfusion (increase or decrease) was the same for both NPWT and manual pressure in 10 of the 12 experiments. In conclusion, laser Doppler can incorrectly record increased perfusion when tissues are compressed, implying that it is flawed in the field of NPWT research as tissues are always compressed to some degree by the NPWT dressing.