Biomimetic strain-stiffening self-assembled hydrogels
Biomimetic strain-stiffening self-assembled hydrogels
复制标题
仿生应变硬化自组装水凝胶
DOI：
10.1002/anie.201911364
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
van Esch Jan H.
中科院分区：
文献类型：
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作者：
Wang Yiming;Xu Zhi;Lovrak Matija;le Sage Vincent A. A.;Zhang Kai;Guo Xuhong;Eelkema Rienk;Mendes Eduardo;van Esch Jan H.
具有应变硬化特性的超分子结构在自然界中普遍存在，但在实验室中仍然很少见。在此，我们报告了完全通过合成分子胶凝剂的自组装产生的应变硬化超分子水凝胶。所涉及的胶凝因子自组装成半柔性纤维，从而交联成水凝胶。有趣的是，这些水凝胶能够响应于施加的应力而硬化，类似于生物中间细丝系统。此外，通过凝胶因子和磷脂的正交自组装构建嵌入脂质体的应变硬化水凝胶网络，在结构和机械性能方面模仿生物组织。这项工作进一步发展了具有机械响应性的仿生软材料，并在组织工程、人工生命和应变传感器等不同领域提出了潜在的诱人应用。
Supramolecular structures with strain‐stiffening properties are ubiquitous in nature but remain rare in the lab. Herein, we report on strain‐stiffening supramolecular hydrogels that are entirely produced through the self‐assembly of synthetic molecular gelators. The involved gelators self‐assemble into semi‐flexible fibers, which thereby crosslink into hydrogels. Interestingly, these hydrogels are capable of stiffening in response to applied stress, resembling biological intermediate filaments system. Furthermore, strain‐stiffening hydrogel networks embedded with liposomes are constructed through orthogonal self‐assembly of gelators and phospholipids, mimicking biological tissues in both architecture and mechanical properties. This work furthers the development of biomimetic soft materials with mechanical responsiveness and presents potentially enticing applications in diverse fields, such as tissue engineering, artificial life, and strain sensors.