Construction

Construction
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DOI:
10.1016/j.neucom.2004.01.070
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发表时间:
2004-06
期刊:
影响因子:
6
通讯作者:
R. G. Feldman
R. G. Feldman
中科院分区:
计算机科学2区
文献类型:
--
作者:
R. G. Feldman

文献摘要

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小鼠脑网络(MBW),一个网络组织的数据库,提供了小鼠脑网络的解剖学上正确的模型的建设。该数据库中的每个网页提供了每个生物学观察到的神经元的位置、方向、形态和推定的突触。MBW被设计为支持(1)按类型映射神经元的空间分布和形态;(2)网络-突触组装的布线;(3)神经元形态和突触到几何多室模型的投影;(4)使用定制的网络爬虫搜索脑网络中的基序和基本电路;以及(5)将解剖学上正确的网络映射到生理学上正确的网络模拟。
The Mouse Brain Web (MBW), a web-organized database, provides for the construction of anatomically correct models of mouse brain networks. Each web page in this database provides the position, orientation, morphology, and putative synapses for each biologically observed neuron. The MBW has been designed to support (1) mapping of the spatial distribution and morphology of neurons by type; (2) wiring of the network–synaptic assembly; (3) projection of neuron morphology and synapses to geometric multi-compartmental models; (4) search for motifs and basic circuits in the brain networks using customized web-crawlers; and (5) the mapping of anatomically correct networks to physiologically correct network simulations.