Multimodal, multidimensional models of mouse brain
Multimodal, multidimensional models of mouse brain
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DOI：
10.1111/j.1528-1167.2007.01244.x
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发表时间：
2007-01-01
期刊：
影响因子：
5.6
通讯作者：
Toga, Arthur W.
中科院分区：
文献类型：
--
作者：
MacKenzie-Graham, Allan J.;Lee, Erh-Fang;Toga, Arthur W.
自然发生的突变体和基因操作的小鼠品系被广泛用于模拟各种人类疾病。酶是一个宝贵的援助，在了解这种操作的影响，提供了一个标准的比较，并促进整合解剖，遗传和生理观察多个科目和实验。我们已经开发了C57 BL/6 J小鼠大脑（成人和新生儿）的数字地图集，作为存储和访问有关小鼠大脑的无数类型信息的综合框架。沿着原始图像和注释图像，这些包含数据库管理系统和一套工具，用于比较来自不同技术和不同动物的信息。每个图谱都建立了小鼠大脑的规范表示，并为新数据的操作和分析提供了工具。我们描述了这两个地图集，并讨论如何将它们用于组织和分析癫痫小鼠模型的数据。
Naturally occurring mutants and genetically manipulated strains of mice are widely used to model a variety of human diseases. Atlases are an invaluable aid in understanding the impact of such manipulations by providing a standard for comparison and to facilitate the integration of anatomic, genetic, and physiologic observations from multiple subjects and experiments. We have developed digital atlases of the C57BL/6J mouse brain (adult and neonate) as comprehensive frameworks for storing and accessing the myriad types of information about the mouse brain. Along with raw and annotated images, these contain database management systems and a set of tools for comparing information from different techniques and different animals. Each atlas establishes a canonical representation of the mouse brain and provides the tools for the manipulation and analysis of new data. We describe both these atlases and discuss how they may be put to use in organizing and analyzing data from mouse models of epilepsy.